| Isolated ileal perforation due to cytomegalovirus reactivation during management of terbinafine hypersensitivity. | |
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MedLine Citation:
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PMID: 20614493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of 71-year-old man who developed a hypersensitivity syndrome associated with terbinafine. He was placed on terbinafine (250 mg/d) for the treatment of tinea pedis due to diabetes mellitus. Following the treatment with terbinafine, he developed drug-induced hypersensitivity syndrome (DIHS). Systemic corticosteroid led to transient improvement of his clinical manifestations. Three months after disease onset, he presented with panperitonitis due to ileal perforation, and underwent an emergency operation. The affected ileum was resected and ileostomy was performed in the terminal ileum. Cytomegalovirus (CMV)-specific IgG antibodies were significantly increased, high-titer CMV antigenemia was detected, and pathological examination of the resected ileum confirmed CMV infection. Based on these observations, we strongly recommend that physicians monitor reactivation of the family of herpesvirus other than herpesvirus 6, to manage DIHS properly. |
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Authors:
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Soichi Sano; Hiroki Ueno; Keiko Yamagami; Yosuke Yakushiji; Yoshihiro Isaka; Isao Kawasaki; Masashi Takemura; Takeshi Inoue; Masayuki Hosoi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 16 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 3339-42 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Osaka City General Hospital, Osaka 534-0021, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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adverse effects Aged Antifungal Agents / adverse effects Cytomegalovirus Infections / complications* Drug Hypersensitivity / complications*, drug therapy Epstein-Barr Virus Infections / etiology Herpesvirus 6, Human Humans Ileal Diseases / etiology* Intestinal Perforation / etiology* Male Naphthalenes / adverse effects* Recurrence Roseolovirus Infections / etiology Tinea Pedis / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Antifungal Agents; 0/Naphthalenes; 91161-71-6/terbinafine |
| Comments/Corrections | |
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