Document Detail

Isolated idiopathic bile ductular hyperplasia in patients with persistently abnormal liver function tests.
MedLine Citation:
PMID:  15030974     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: In routine examination of liver biopsies isolated ductular hyperplasia (IDH) may be the only histopathological change. Here we describe the clinical and immunophenotypic features of a number of cases retrospectively identified reviewing consecutive liver biopsies from five Italian centers over 4 years.
METHODS: We reviewed 1235 cases biopsied for chronic liver disease (1078 for viral hepatitis). Records of cases fulfilling the inclusion criteria for IDH were reviewed to identify possible aetiologies. Biopsies showing IDH and control biopsies were studied by immunohistochemistry for cytokeratin-7, epithelial-membrane-antigen (EMA), neural-cell-adhesion-molecule (NCAM), Ki-67.
RESULTS: Out of 70 biopsies fulfilling IDH criteria, 16 (22.8%) were of unknown aetiology. Patients with idiopathic IDH (age 38.2+/-11 years) were asymptomatic with mild, long-lasting ALT and/or gammaGT increases. A significant increase of well-differentiated (EMA-positive; NCAM-negative) bile ductules localized at the portal interface and inside the lobule was found in idiopathic IDH.
CONCLUSIONS: Idiopathic IDH was present in 10% of adults biopsied for persistent mild liver function test abnormalities unrelated to viral hepatitis. In contrast with the ductular reaction seen in many forms of liver disease, it is characterized by well-differentiated hyperplastic ductules in absence of significant inflammation, and may represent a non-specific pattern of reaction to mild liver damages.
Aurelio Sonzogni; Guido Colloredo; Luca Fabris; Massimiliano Cadamuro; Bruno Paris; Luigi Roffi; Massimo Pozzi; Giorgio Bovo; Paolo Del Poggio; Bernard C Portmann; Mario Strazzabosco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hepatology     Volume:  40     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-19     Completed Date:  2004-11-10     Revised Date:  2012-02-22    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  592-8     Citation Subset:  IM    
Department of Pathology, Ospedali Riuniti, Bergamo, Italy.
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MeSH Terms
Bile Ducts, Intrahepatic / metabolism,  pathology*
Case-Control Studies
Keratins / metabolism
Liver Function Tests
Middle Aged
Mucin-1 / metabolism
Neural Cell Adhesion Molecules / metabolism
Retrospective Studies
Grant Support
Reg. No./Substance:
0/KRT7 protein, human; 0/Keratin-7; 0/Mucin-1; 0/Neural Cell Adhesion Molecules; 68238-35-7/Keratins

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