Document Detail


Isolated eyelid edema in Melkersson-Rosenthal syndrome: a case series.
MedLine Citation:
PMID:  22056858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To report the clinicopathologic features of a series of patients with Melkersson-Rosenthal syndrome (MRS).
METHODS: Patients in this clinicopathological case series were identified through retrospective review. Five Caucasian patients (2 women and 3 men; age range, 46 to 73 years) with isolated eyelid swelling presented over an 11-month period to two Canadian tertiary Oculoplastic referral centres. All underwent clinical examination and had tissue biopsies.
RESULTS: The patients presented with non-pitting, non-pruritic, painless and recurrent eyelid swelling. None had evidence of cranial nerve palsy or fissured tongue. The duration of symptoms before referral was between 1-5 years. Histopathological examination showed granulomatous inflammation in four patients. Granulomatous folliculitis was a novel finding in three patients.
CONCLUSIONS: Monosymptomatic patients with MRS require a high index of suspicion. Histopathological confirmation is vital for the diagnosis.
Authors:
N G Rawlings; A A Valenzuela; L H Allen; J G Heathcote
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-11-04
Journal Detail:
Title:  Eye (London, England)     Volume:  26     ISSN:  1476-5454     ISO Abbreviation:  Eye (Lond)     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-12     Completed Date:  2012-03-15     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology and Visual Sciences, QEII Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex Hormones / therapeutic use
Aged
Biopsy
Diagnosis, Differential
Edema / drug therapy
Eyelid Diseases / drug therapy,  pathology*
Eyelids / pathology*
Female
Humans
Male
Melkersson-Rosenthal Syndrome / drug therapy,  pathology*
Middle Aged
Retrospective Studies
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones
Comments/Corrections
Comment In:
Eye (Lond). 2012 Jun;26(6):893; author reply 893-4   [PMID:  22422032 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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