Document Detail

Isolated epithelioid cells from disaggregated BCG granulomas - some functional studies.
MedLine Citation:
PMID:  7057294     Owner:  NLM     Status:  MEDLINE    
Isolated epithelial cells from disaggregated rat BCG granulomas show a morphological spectrum from "plasmacytoid" to "vesicular" froms on electron microscopy. Functional studies on these isolated cells showed that all epithelial cells exhibited poor trypsin-resistant glass adherence and poor phagocytosis of latex, zymosan, antibody coated and complement coated and complement coated erythrocytes when compared with macrophages, especially at the vesicular end of the spectrum. A high proportion of all epithelioid cell types was found to have Fc surface receptors but C3 receptors were reduced on vesicular cells compared with the plasmacytoid variety. The findings indicate that the progressive transformation of mononuclear phagocytes into vesicular epithelioid cells through plasmacytoid intermediates is accompanied by a concomitant modification of cell function. The significance of these changes is discussed.
G T Williams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pathology     Volume:  136     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-04-22     Completed Date:  1982-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  15-25     Citation Subset:  IM    
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MeSH Terms
BCG Vaccine*
Cell Adhesion
Cell Separation
Epithelium / physiopathology
Granuloma / pathology,  physiopathology*
Microscopy, Electron
Rats, Inbred Strains
Receptors, Immunologic / analysis
Skin / ultrastructure
Skin Diseases / pathology,  physiopathology*
Reg. No./Substance:
0/BCG Vaccine; 0/Receptors, Immunologic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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