Document Detail

Isolated congenital heart block.
MedLine Citation:
PMID:  20978575     Owner:  NLM     Status:  MEDLINE    
Isolated congenital heart block, frequently seen in mothers who have connective-tissue disease, can be transmitted to the fetus through transplacental passage of anti-Ro/SSA and anti-La/SSB autoantibodies. Even if the antibodies appear transiently in the fetal circulation, the block is permanent and can require pacemaker implantation. Complete congenital heart block is seen in 1% to 5% of neonates born to mothers who carry these autoantibodies. Herein, we report the case of a baby-born to a 31-year-old asymptomatic woman-who manifested congenital heart block in utero, at 30 weeks of gestation. During gestation and following birth, no further problems were detected. At her last follow-up appointment, 8 years later, the girl still had no clinical symptoms, and exercise increased her heart rate despite complete heart block. We report this case for its unique presentation, and we discuss isolated congenital heart block within the context of the inadequate literature on its pathogenesis and treatment.
F Sedef Tunaoglu; Ayse Yildirim; Dogus Vurali
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital     Volume:  37     ISSN:  1526-6702     ISO Abbreviation:  Tex Heart Inst J     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-27     Completed Date:  2011-02-11     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8214622     Medline TA:  Tex Heart Inst J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  579-83     Citation Subset:  IM    
Department of Pediatric Cardiology, Gazi University Medical Faculty, 1060 Ankara, Turkey.
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MeSH Terms
Autoantibodies / blood
Child, Preschool
Electrocardiography, Ambulatory
Exercise Test
Gestational Age
Heart Block / congenital*,  diagnosis,  immunology,  physiopathology
Heart Rate, Fetal
Infant, Newborn
Lupus Erythematosus, Systemic / congenital,  diagnosis,  immunology,  physiopathology
Maternal-Fetal Exchange
Ultrasonography, Prenatal / methods
Reg. No./Substance:

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