Document Detail


Isolated clubfoot diagnosed prenatally: is karyotyping indicated?
MedLine Citation:
PMID:  10711559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the appropriateness of fetal karyotyping after prenatal sonographic diagnosis of isolated unilateral or bilateral clubfoot. METHODS: We retrospectively reviewed a database of fetal abnormalities diagnosed by ultrasound at a single tertiary referral center from July 1994 to March 1999 for cases of unilateral or bilateral clubfoot. Fetuses who had additional anomalies diagnosed prenatally, after targeted sonographic fetal anatomy surveys, were excluded. Outcome results included fetal karyotype diagnosed by amniocentesis, or newborn physical examination by a pediatrician. RESULTS: During the 5-year period, 5,731 fetal abnormalities were diagnosed from more than 27,000 targeted prenatal ultrasound examinations. There were 51 cases of isolated clubfoot. The mean maternal age at diagnosis was 30.5 years. The mean gestational age at diagnosis was 21.6 weeks. Twenty-three of the women (45%) were at increased risk of fetal aneuploidy, on the basis of advanced maternal age or abnormal maternal serum screening. Six women (12%) had positive family histories of clubfoot; however, no cases of aneuploidy were found by fetal karyotype evaluation or newborn physical examination. All cases of clubfoot diagnosed prenatally were confirmed at newborn physical examination, and no additional malformations were detected. CONCLUSION: After prenatal diagnosis of isolated unilateral or bilateral clubfoot, there appeared to be no indication to offer karyotyping, provided that a detailed sonographic fetal anatomy survey was normal and there were no additional indications for invasive prenatal diagnoses.
Authors:
F D Malone; T Marino; D W Bianchi; K Johnston; M E D'Alton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  95     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-22     Completed Date:  2000-03-22     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  437-40     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, Columbia-Presbyterian Medial Center, New York, New York 10032, USA. malonef@zeus.cpmc.columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Clubfoot / ultrasonography*
Female
Humans
Karyotyping
Male
Retrospective Studies
Ultrasonography, Prenatal*

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