Document Detail

Isolated cardiac preparations: models of intrinsic myocardial dysfunction in circulatory shock.
MedLine Citation:
PMID:  3995693     Owner:  NLM     Status:  MEDLINE    
Isolated cardiac preparations have been adapted for modeling intrinsic myocardial responses to circulatory shock syndromes independently of immediate influence from depressive or supportive constraints operative in the intact host. Left atrial and left ventricular (LV) papillary muscles and coronary-perfused hearts were removed from guinea pigs during development of Escherichia coli endotoxin shock. Preparations were then subjected to a battery of functional analyses under conditions of constant perfusate pH, pO2, pCO2, electrolyte and substrate concentrations, osmolality, and temperature. Evidence for contractile depression intrinsic to the myocardium itself was a consistent and reproducible finding in all three tissue models. The LV mechanical disadvantage of shock hearts was not correlated with changes in cardiac cycle length (beating frequency), active state duration (contraction-relaxation intervals), or tissue water content; neither was it surmounted by maximally effective increments in coronary flow, [Ca2+]o, or diastolic fiber length. Taken in concert, studies to date suggest that gram-negative endotoxin leads in some way to a reduction of intrinsic contractile reserves of the myocardium, and we have postulated that this change underlies the circulatory shock phase of endotoxicosis. The experimental approach embodied in these models may yield unique cardiodynamic interpretations that will allow the formulation of testable hypotheses about the pathogenesis and prevention of intrinsic cardiac complications of endotoxin and related shock forms.
J L Parker; H R Adams
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulatory shock     Volume:  15     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1985  
Date Detail:
Created Date:  1985-07-12     Completed Date:  1985-07-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-45     Citation Subset:  IM    
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MeSH Terms
Calcium / metabolism
Coronary Circulation*
Guinea Pigs
Heart Atria / physiopathology
Heart Ventricles / physiopathology
Myocardial Contraction*
Papillary Muscles / physiopathology
Shock / physiopathology*
Shock, Septic / physiopathology
Grant Support
Reg. No./Substance:

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