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Isolated bone marrow non-Hodgkin's lymphoma. Report of two cases and literature review.
MedLine Citation:
PMID:  12719030     Owner:  NLM     Status:  Publisher    
We report two patients with isolated bone marrow non-Hodgkin's lymphoma and we review the additional 23 cases thus far described. Bicytopenia or pancytopenia and an elevated erythrocyte sedimentation rate were universally present. Some 84% of the patients manifested fever of unknown origin (FUO), 64% constitutional symptoms, 48% hepatomegaly, and 52% splenomegaly. Of the variety of therapeutic protocols used, corticosteroids, alone or in combination, appeared to be the most effective. Survival ranged from 1 week to 4.5 years. Early diagnosis would avoid unnecessary work-up in patients with FUO and enable optimization of therapy.
S Chachashvili; D Almoznino-Sarafian; R Yona; J Sandbank; M Shteinshnaider; D Modai; N Cohen
Publication Detail:
Journal Detail:
Title:  European journal of internal medicine     Volume:  14     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-Apr-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  116-119     Citation Subset:  -    
Department of Internal Medicine 'F', Assaf Harofeh Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 70300, Zerifin, Israel
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