Document Detail

Isolated anaemia as a manifestation of Rh isoimmunisation.
MedLine Citation:
PMID:  22665873     Owner:  NLM     Status:  MEDLINE    
Rh isoimmunisation leads to haemolytic anaemia and hyperbilirubinaemia in the first h of life. Isolated early onset neonatal anaemia has rarely been reported. The authors describe the case of a term infant, born to an 'A' negative, second gravida mother. On the second day of life, pallor was noticed. His haemoglobin (Hb) was 6.8 g/dl, he had reticulocytosis and a positive direct antiglobulin test. However, he did not have a high total serum bilirubin (TSB) (87.2 μmol/l). He was transfused with red blood cells and kept under phototherapy for 3 days. Three weeks later, he received another transfusion for severe anaemia (Hb 6 5 g/dl). During this period, he was never jaundiced and the maximum level of TSB was 122 μmol/l. On follow-up, his Hb stabilised and he had no further problems. This report highlights the possibility of early onset anaemia without jaundice as the sole manifestation of Rh isoimmunisation.
Juliana Roda; Gabriela Mimoso; Manuela Benedito; Dolores Faria Pereira
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-01-18
Journal Detail:
Title:  BMJ case reports     Volume:  2012     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-05     Completed Date:  2013-02-01     Revised Date:  2014-01-27    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Anemia, Macrocytic / etiology*,  immunology,  therapy
Bilirubin / blood
Erythrocyte Transfusion
Folic Acid / therapeutic use
Hemoglobins / analysis
Infant, Newborn
Infant, Newborn, Diseases / etiology*,  immunology,  therapy
Rh Isoimmunization / complications*,  immunology,  therapy
Reg. No./Substance:
0/Hemoglobins; 935E97BOY8/Folic Acid; RFM9X3LJ49/Bilirubin

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