| Isolated absent or hypoplastic nasal bone in the second trimester fetus: is amniocentesis necessary? | |
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MedLine Citation:
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PMID: 21375370 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective. To elucidate the significance of isolated absent or hypoplastic nasal bone in the second trimester ultrasound scan. Methods. All cases of absent or hypoplastic nasal bone (length < 5th percentile) encountered during 2007-2009 were retrieved from database and all the ultrasound findings including structural abnormalities and soft markers for Down syndrome and fetal karyotype were reviewed. The cases were categorized into a study group with isolated absent or hypoplastic nasal bone and a comparison group with additional ultrasound findings. The incidence of Down syndrome confirmed by karyotyping was compared between the two groups. Results. Among 14 fetuses with absent or hypoplastic nasal bone identified, six (42.9%) had Down syndrome and eight (57.1%) were normal. All (100%) of the six fetuses with isolated absent or hypoplastic nasal bone (Study Group) had normal karyotype, while six (75%) of the other eight fetuses with additional ultrasound findings (Comparison Group) had Down syndrome (p = 0.010). Conclusions. The use of isolated absent or hypoplastic nasal bone in the second trimester ultrasound scan for Down syndrome screening may not be effective. Amniocentesis, however, is indicated for fetuses with structural abnormality or additional soft marker which should be carefully searched by an experienced ultrasonographer. |
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Authors:
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Yuen Ha Ting; Terence T Lao; Tze Kin Lau; Man Kin Chung; Tak Yeung Leung |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 24 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 555-8 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Fetal Medicine Unit, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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