| Isolated Tramadol Overdose Associated with Brugada ECG Pattern. | |
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MedLine Citation:
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PMID: 21039643 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. We report a case of isolated tramadol overdose associated with a Brugada ECG pattern. A review of the literature reveals no previous human cases of tramadol overdose causing ECG changes consistent with sodium-channel blockade. However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication. (PACE 2010; 1-3). |
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Authors:
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Jon B Cole; Srinivasan Sattiraju; Elisabeth F Bilden; Richard W Asinger; Stefan C Bertog |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-10-7 |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: - ISSN: 1540-8159 ISO Abbreviation: - Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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©2010, The Authors. No claim to original US government works. |
Affiliation:
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Hennepin Regional Poison Center, Minneapolis, Minnesota Hennepin County Medical Center, Minneapolis, Minnesota University of Minnesota, Minneapolis, Minnesota Veterans Affairs Medical Center, Minneapolis, Minnesota. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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