Document Detail

Isokinetic muscle strength predicts maximum exercise tolerance in renal patients on chronic hemodialysis.
MedLine Citation:
PMID:  2382645     Owner:  NLM     Status:  MEDLINE    
Patients with end-stage renal disease receiving chronic hemodialysis have impaired exercise tolerance. To distinguish between a central cardiorespiratory and a peripheral skeletal muscular origin for this fatigue, we measured exercise performance and peak oxygen consumption during a maximum exercise test in 10 patients receiving chronic hemodialysis. Skeletal muscle function was measured with an isokinetic cycle ergometer and a Cybex II isokinetic dynamometer. Peak rates of oxygen consumption (17.7 +/- 3.6 [mean +/- SD] mL O2/kg/min), blood lactate concentrations (3.4 +/- 0.9 mmol/L), peak heart rates (168 +/- 12 beats/min), and rates of ventilation (37.3 +/- 14.6 L/min) were low, but respiratory exchange ratios (1.1 +/- 0.1) were compatible with maximal effort. There was a significant correlation between isokinetic muscle strength and VO2 peak, exercise duration, peak ventilation, and peak blood lactate concentrations (P less than 0.05 to less than 0.001), but not between hemoglobin concentration, total blood hemoglobin content, or hematocrit and these variables. Therefore, in renal dialysis patients, isokinetic muscle strength is a better predictor of exercise capacity than are variables determining blood oxygen carrying capacity. This suggests that altered skeletal muscle function explains the impaired exercise tolerance of anemic patients with end-stage renal disease receiving chronic hemodialysis.
W Diesel; T D Noakes; C Swanepoel; M Lambert
Related Documents :
15474695 - Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in...
11378005 - Influence of carvedilol on the benefits of physical training in patients with moderate ...
2382645 - Isokinetic muscle strength predicts maximum exercise tolerance in renal patients on chr...
3946215 - Exercise ventilation and pulmonary artery wedge pressure in chronic stable congestive h...
7759705 - Effects of short-term aminophylline administration on cardiac functional reserve in pat...
1597175 - Physiological and perceptual responses to load-carrying in female subjects using intern...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  16     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-07     Completed Date:  1990-09-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Department of Physiology, University of Cape Town Medical School, Observatory, South Africa.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Exercise / physiology*
Exercise Test
Hemoglobins / analysis
Kidney Failure, Chronic / physiopathology*,  therapy
Lactates / blood
Lactic Acid
Middle Aged
Muscle Contraction / physiology*
Oxygen Consumption / physiology
Physical Endurance / physiology*
Renal Dialysis*
Reg. No./Substance:
0/Hemoglobins; 0/Lactates; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Recombinant human erythropoietin and phlebotomy in the treatment of iron overload in chronic hemodia...
Next Document:  Introduction of percutaneous arteriovenous femoral shunt: a new access for continuous arteriovenous ...