Document Detail


Isokinetic muscle strength predicts maximum exercise tolerance in renal patients on chronic hemodialysis.
MedLine Citation:
PMID:  2382645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with end-stage renal disease receiving chronic hemodialysis have impaired exercise tolerance. To distinguish between a central cardiorespiratory and a peripheral skeletal muscular origin for this fatigue, we measured exercise performance and peak oxygen consumption during a maximum exercise test in 10 patients receiving chronic hemodialysis. Skeletal muscle function was measured with an isokinetic cycle ergometer and a Cybex II isokinetic dynamometer. Peak rates of oxygen consumption (17.7 +/- 3.6 [mean +/- SD] mL O2/kg/min), blood lactate concentrations (3.4 +/- 0.9 mmol/L), peak heart rates (168 +/- 12 beats/min), and rates of ventilation (37.3 +/- 14.6 L/min) were low, but respiratory exchange ratios (1.1 +/- 0.1) were compatible with maximal effort. There was a significant correlation between isokinetic muscle strength and VO2 peak, exercise duration, peak ventilation, and peak blood lactate concentrations (P less than 0.05 to less than 0.001), but not between hemoglobin concentration, total blood hemoglobin content, or hematocrit and these variables. Therefore, in renal dialysis patients, isokinetic muscle strength is a better predictor of exercise capacity than are variables determining blood oxygen carrying capacity. This suggests that altered skeletal muscle function explains the impaired exercise tolerance of anemic patients with end-stage renal disease receiving chronic hemodialysis.
Authors:
W Diesel; T D Noakes; C Swanepoel; M Lambert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  16     ISSN:  0272-6386     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-07     Completed Date:  1990-09-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Affiliation:
Department of Physiology, University of Cape Town Medical School, Observatory, South Africa.
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MeSH Terms
Descriptor/Qualifier:
Adult
Exercise / physiology*
Exercise Test
Female
Hemoglobins / analysis
Humans
Kidney Failure, Chronic / physiopathology*,  therapy
Lactates / blood
Lactic Acid
Male
Middle Aged
Muscle Contraction / physiology*
Oxygen Consumption / physiology
Physical Endurance / physiology*
Renal Dialysis*
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Lactates; 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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