Document Detail


Isoforms of apolipoprotein C-I associated with individuals with coronary artery disease.
MedLine Citation:
PMID:  21187063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apolipoprotein C-I (apoC-I) is a 6.6kDa serum protein associated with high density lipoproteins (HDL) and triglyceride-rich lipoproteins. In this study, apoC-I was examined in high density lipoprotein subfractions from individuals with and without coronary artery disease (CAD). New isoforms of apoC-I, were detected in the cohort of individuals with CAD using mass spectrometry while the expected apoC-I isoforms were absent. In addition, the apoC-I mass spectra for the CAD cohort had satellite peaks indicative of the involvement of oxidative processes. Further analysis of the mass spectra of the CAD and non-CAD cohorts suggest that the origin of these new isoforms may be due to genetic mutations that could compromise the function of apoC-I.
Authors:
D'Vesharronne Moore; Catherine McNeal; Ronald Macfarlane
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-25
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  404     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-03-11     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1034-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Apolipoprotein C-I / blood,  genetics,  metabolism*
Cohort Studies
Coronary Artery Disease / blood,  metabolism*
Humans
Oxidation-Reduction
Protein Isoforms / blood,  genetics,  metabolism
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Grant Support
ID/Acronym/Agency:
R01 HL068794/HL/NHLBI NIH HHS; R01 HL068794-07/HL/NHLBI NIH HHS; R01HL068794/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein C-I; 0/Protein Isoforms
Comments/Corrections

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