| Isoforms of apolipoprotein C-I associated with individuals with coronary artery disease. | |
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MedLine Citation:
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PMID: 21187063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Apolipoprotein C-I (apoC-I) is a 6.6kDa serum protein associated with high density lipoproteins (HDL) and triglyceride-rich lipoproteins. In this study, apoC-I was examined in high density lipoprotein subfractions from individuals with and without coronary artery disease (CAD). New isoforms of apoC-I, were detected in the cohort of individuals with CAD using mass spectrometry while the expected apoC-I isoforms were absent. In addition, the apoC-I mass spectra for the CAD cohort had satellite peaks indicative of the involvement of oxidative processes. Further analysis of the mass spectra of the CAD and non-CAD cohorts suggest that the origin of these new isoforms may be due to genetic mutations that could compromise the function of apoC-I. |
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Authors:
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D'Vesharronne Moore; Catherine McNeal; Ronald Macfarlane |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-25 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 404 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-03-11 Revised Date: 2012-01-31 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 1034-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory for Cardiovascular Chemistry, Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoprotein C-I
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blood,
genetics,
metabolism* Cohort Studies Coronary Artery Disease / blood, metabolism* Humans Oxidation-Reduction Protein Isoforms / blood, genetics, metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL068794-07/HL/NHLBI NIH HHS; R01HL068794/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein C-I; 0/Protein Isoforms |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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