Document Detail


Isoform-specific modulation of Na+, K+-ATPase alpha-subunit gene expression in hypertension.
MedLine Citation:
PMID:  2838907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium, potassium-adenosine triphosphatase (Na+, K+-ATPase) is hypothesized to be involved in systemic vascular hypertension through its effects on smooth muscle reactivity and myocardial contractility. By means of RNA blot analyses of cardiac, aortic, and skeletal muscle RNAs in two rat hypertensive models, Na+,K+-ATPase alpha-subunit messenger RNA isoforms (alpha 2 and alpha 3) were shown to be deinduced in response to increased intravascular pressure. The changes were observed after 48 hours or more of experimental hypertension. Under these conditions, there is coordinate induction of another alpha isoform (alpha 1) and of beta-subunit messenger RNAs, probably in response to alterations in sodium flux rather than to elevated blood pressure.
Authors:
V L Herrera; A V Chobanian; N Ruiz-Opazo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  241     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-03     Completed Date:  1988-08-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-3     Citation Subset:  IM    
Affiliation:
Section of Molecular Genetics, Boston University Medical Center, MA 02118.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II
Animals
Cardiomegaly / enzymology,  genetics
Desoxycorticosterone
Heart Ventricles / enzymology
Hypertension / enzymology,  genetics*
Isoenzymes / genetics
RNA, Messenger / genetics
Rats
Sodium-Potassium-Exchanging ATPase / genetics*
Grant Support
ID/Acronym/Agency:
HL01967/HL/NHLBI NIH HHS; HL18318/HL/NHLBI NIH HHS; HL39267/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/RNA, Messenger; 11128-99-7/Angiotensin II; 64-85-7/Desoxycorticosterone; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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