Document Detail

Isoflurane and sevoflurane during reperfusion prevent recovery from ischaemia in mitochondrial KATP channel blocker pretreated hearts.
MedLine Citation:
PMID:  16426466     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Inhalation anaesthetics given only during post-ischaemic reperfusion have some protective effect against reperfusion injury in the heart. Adenosine triphosphate-regulated mitochondrial potassium channels have been shown to be an important mediator of cardioprotection. Thus, we investigated whether 5-hydroxydecanoate, a putative mitochondrial potassium channel blocker, prevents the cardioprotective effect of volatile anaesthetics. METHODS: Forty rats were randomly allocated to four groups of equal size: control group, 5-hydroxydecanoate group, 5-hydroxydecanoate + sevoflurane group and 5-hydroxydecanoate + isoflurane group. Seven minutes after the start of perfusion, normal saline (control group) or 5-hydroxydecanoate (the other groups) was administered. Ten minutes after the start of perfusion, the heart was rendered globally ischaemic for 10 min. One minute before the end of the ischaemic period, 2.7% sevoflurane or 1.4% isoflurane were administered in the 5-hydroxydecanoate + sevoflurane or 5-hydroxydecanoate + isoflurane groups respectively. The heart was reperfused for 10 min. RESULTS: Adenosine triphosphate content at the end of reperfusion in the 5-hydroxydecanoate + sevoflurane group was significantly lower (P < 0.05) than those in the control and the 5-hydroxydecanoate + isoflurane groups (19.9 +/- 8.7, 28.1 +/- 3.4 and 30.4 +/- 2.3 micromol g(-1), respectively). In addition, the combination of inhalation anaesthetics and 5-hydroxydecanoate decreased the ratios of recovered hearts from ischaemia (5-hydroxydecanoate + sevoflurane group: 40%, 5-hydroxydecanoate + isoflurane group 50%). CONCLUSION: 5-hydroxydecanoate alone caused no significant changes in haemodynamics and myocardial metabolism. However, the combination of 5-hydroxydecanoate and volatile anaesthetics impaired the recovery from ischaemia. Although animal data cannot be extrapolated to human beings, we suggest that more attention be paid to patients on sulphonylurea drugs, which inhibit potassium channels, when they are anaesthetized with volatile anaesthetics.
K Masui; S Kashimoto; A Furuya; T Oguchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  23     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-05-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
University of Yamanashi, Faculty of Medicine, Department of Anesthesiology, Yamanashi, Japan.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Decanoic Acids / pharmacology*
Hemodynamics / drug effects
Hydroxy Acids / pharmacology*
Ischemic Preconditioning, Myocardial
Isoflurane / pharmacology*
Methyl Ethers / pharmacology*
Mitochondria, Heart / drug effects*
Myocardial Reperfusion*
Myocardial Reperfusion Injury / metabolism*,  physiopathology
Potassium Channel Blockers / pharmacology*
Potassium Channels / drug effects*
Rats, Wistar
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Decanoic Acids; 0/Hydroxy Acids; 0/Methyl Ethers; 0/Potassium Channel Blockers; 0/Potassium Channels; 0/mitochondrial K(ATP) channel; 26675-46-7/Isoflurane; 28523-86-6/sevoflurane; 624-00-0/5-hydroxydecanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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