Document Detail


Isoflurane-induced protection against myocardial stunning is independent of adenosine 1 (A(1)) receptor in isolated rat heart.
MedLine Citation:
PMID:  11493499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Volatile anaesthetics can pharmacologically enhance the recovery of stunned myocardium, but the mechanism is still unknown. This study sought to determine whether isoflurane attenuates myocardial stunning, and whether the myocardial protection of isoflurane is mediated by adenosine A(1) receptors. Five groups (n=8) of isolated rat hearts were studied in the Langendorff apparatus. The control groups underwent 20-min ischaemia with or without adenosine receptor antagonist (DPCPX, A(1)()selective) treatment (Cont group and DPCPX group). In the isoflurane groups, isoflurane (1.5 MAC) was present throughout the experiment (Iso group) and DPCPX (200 nM) was administered from 10 min before ischaemia (Iso+DPCPX(pre-I) group) or the beginning of reperfusion (Iso+DPCPX(post-I) group) to the end of experiment. The isoflurane groups had a lower end-diastolic pressure than the control groups (P<0.05). Developed pressure recovered to 77, 76, and 82% in Iso, Iso+DPCPX(pre-I) and Iso+DPCPX(post-I) groups, respectively (P<0.05 compared with control groups). LV+dp/dt(max) recovered to 53, 86, 81, 84, and 60% of pre-ischaemic values in Cont, Iso, Iso+DPCPX(pre-I), Iso+DPCPX(post-I), and DPCPX groups. LV-dp/dt(min) recovered to 55, 84, 83, 81, and 62%, respectively. Both LV+dp/dt(max) and LV-dp/dt(min) were significantly different (P<0.05) between control and isoflurane groups during reperfusion. There were no significant differences among the isoflurane groups. Our data show that isoflurane enhances the post-ischaemic functional recovery of isolated rat heart and that block of A(1) receptors does not abolish the beneficial effects of isoflurane. We conclude that A(1)()receptors are not involved in isoflurane-induced myocardial protection in the isolated rat heart.
Authors:
L Yao; R Kato; P Foëx
Related Documents :
7867119 - A comparison of sevoflurane with halothane, enflurane, and isoflurane on bronchoconstri...
8863109 - Comparison of four methods of automated recording of physiologic data at one minute int...
7327999 - Anesthesia of small kangaroos.
19933529 - Positive intravascular test dose criteria in children during total intravenous anesthes...
2265159 - Effects of an intravenously administered arrhythmogenic dose of bupivacaine at the nucl...
16261469 - Combined spinal-propofol anesthesia with noninvasive positive-pressure ventilation.
10737129 - Is there any difference between intermediate-acting and long-acting calcium antagonists...
6672919 - Cardiopulmonary response to acute altitude exposure: water loading and denitrogenation.
11162419 - Correlation between increased airway responsiveness and severity of pulmonary edema.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  87     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-08     Completed Date:  2002-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  258-65     Citation Subset:  IM    
Affiliation:
Nuffield Department of Anaesthetics, Oxford University, Radcliffe Infirmary, Woodstock Road, Oxford OX2 6HE, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anesthetics, Inhalation / therapeutic use*
Animals
Diastole / drug effects
Isoflurane / therapeutic use*
Male
Myocardial Contraction / drug effects
Myocardial Stunning / physiopathology,  prevention & control*
Organ Culture Techniques
Rats
Rats, Wistar
Receptors, Purinergic P1 / antagonists & inhibitors,  physiology*
Xanthines / pharmacology
Chemical
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Receptors, Purinergic P1; 0/Xanthines; 102146-07-6/1,3-dipropyl-8-cyclopentylxanthine; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A reduction in type and screen: preoperative prediction of RBC transfusions in surgery procedures wi...
Next Document:  Aerosolized surfactant therapy for endotoxin-induced experimental acute respiratory distress syndrom...