| Isoflurane impairs the function of ischemic myocardium in acutely but not in chronically instrumented dogs. | |
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MedLine Citation:
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PMID: 1858986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To compare the effects of isoflurane on ischemic myocardium in acutely and chronically instrumented animals, 12 mongrel dogs were monitored with electromagnetic or Doppler ultrasonic flow transducers and hydraulic occluders around the left circumflex coronary artery, pressure transducers in the left ventricle, and heparin-filled catheters in the descending aorta. Regional function of normal and ischemic myocardium was assessed by sonomicrometry. The hemodynamic effects of isoflurane (2% inspired concentration) were more pronounced in the acutely than in the chronically instrumented dogs. Decreases in mean arterial pressure (-47% +/- 5% in the acute and -22% +/- 4% in the chronic preparation, P less than 0.01), left ventricular contractility (-51% +/- 6% and -33% +/- 4%, P less than 0.01), and coronary perfusion pressure (-59% +/- 6% and -12% +/- 9%, P less than 0.01) were more distinct in the acutely instrumented animals. Although the reduction of regional function during isoflurane anesthesia was similar in normal myocardium in both preparations (-33% +/- 4% acute and -34% +/- 6% chronic preparation, not a significant difference), an exaggerated dysfunction was observed in the ischemic myocardium of the acutely instrumented dogs (-66% +/- 2% and -30% +/- 4%, P less than 0.01). It is concluded that acutely instrumented dogs respond to the hemodynamic effects of isoflurane, resulting in ischemic myocardial dysfunction, significantly more than do chronically instrumented dogs. |
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Authors:
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N Mayer; M Zimpfer; K Steinbereithner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 73 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-08-29 Completed Date: 1991-08-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 16-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia and General Intensive Care, University of Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / physiopathology* Dogs Female Heart / drug effects*, physiopathology Hemodynamics / drug effects*, physiology Isoflurane / toxicity* Male |
| Chemical | |
Reg. No./Substance:
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26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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