Document Detail

Isoflurane attenuates cAMP-mediated vasodilation in rat microvessels.
MedLine Citation:
PMID:  7586449     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Endothelium-dependent vasodilation mediated by cGMP is known to be attenuated by the inhalational anesthetic isoflurane. The present study examines the effect of isoflurane on beta-adrenergic and cAMP-mediated vasodilation. METHODS AND RESULTS: Fifty-three subepicardial coronary arteries (diameter, 103 +/- 13 microns) from Wistar rats were studied in vitro in a pressurized (40 mm Hg), no-flow state with use of optical density video detection system. After preconstriction of vessels with the thromboxane A2 analogue U46619 10(-6) mol/L, concentration response curves to the nonselective beta-adrenergic agonist isoproterenol, the Gs protein activator sodium fluoride, the adenylate cyclase activator forskolin, the cAMP analogue 8-Br-cAMP, or the phosphodiesterase inhibitor RO20-1724 were obtained either in the presence of absence (control) of 2% isoflurane. Relaxations to all the agents tested were significantly reduced in the presence of isoflurane compared with controls. CONCLUSIONS: Isoflurane attenuates cAMP-mediated vasodilation. The impairment appears to be distal to adenylate cyclase and is not due to enhancement of cAMP phosphodiesterase.
K W Park; H B Dai; E Lowenstein; A Darvish; F W Sellke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  92     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-28     Completed Date:  1995-12-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  II423-7     Citation Subset:  AIM; IM    
Department of Anesthesia and Critical Care, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA.
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MeSH Terms
Adrenergic beta-Agonists / pharmacology
Cyclic AMP / physiology*
Isoflurane / pharmacology*
Isoproterenol / pharmacology
Microcirculation / drug effects
Rats, Wistar
Stimulation, Chemical
Vasodilation / drug effects*,  physiology
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Agonists; 26675-46-7/Isoflurane; 60-92-4/Cyclic AMP; 7683-59-2/Isoproterenol

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