Document Detail

Isoflavonoid glucosides are deconjugated and absorbed in the small intestine of human subjects with ileostomies.
MedLine Citation:
PMID:  17413104     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although soy isoflavonoids have a number of health-promoting benefits, information concerning the sites of their absorption and metabolism in humans remains limited. Isoflavonoid absorption from the gut requires deconjugation of glucosides to aglycones. OBJECTIVE: The objective was to investigate the role of the small intestine in isoflavonoid absorption and metabolism in humans. DESIGN: Human subjects with fully functional gastrointestinal tracts (n = 6) and ileostomy subjects (n = 6) were fed a single soy meal containing 64.8 mg isoflavonoid aglycone equivalents (95% as glucosides). Metabolism of isoflavonoids in the upper gastrointestinal tract was examined by analyzing ileal effluent from ileostomy subjects, and absorption was assessed indirectly by quantifying isoflavonoids and several metabolites in 24-h urine pools. RESULTS: Chyme contained 36.7% of ingested isoflavonoid aglycone equivalents, primarily (95.8%) as aglycones. Qualitative profiles (x +/- SEM) of isoflavonoid excretion in urine (daidzein > glycitein > genistein) and the quantity of isoflavonoid equivalents were not significantly different between the control (18.4 +/- 2.2 mg) and ileostomy (13.5 +/- 3.2 mg) subjects. Dihydrodaidzein was present in the urine of all subjects, although the amount excreted by ileostomy subjects was less than that excreted by the control subjects. The percentage of producers and mean quantities of dihydrogenistein, equol, and O-desmethylangolensin in the urine of ileostomy subjects also were lower than those of control subjects. CONCLUSIONS: Ileostomy subjects efficiently deglycosylate isoflavonoid glucosides in the small intestine and appear to absorb aglycones with an efficiency comparable with that of control subjects. However, the production of microbial metabolites of isoflavonoids is limited in ileostomy subjects.
Kelly R Walsh; Sara J Haak; Torsten Bohn; Qingguo Tian; Steven J Schwartz; Mark L Failla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  85     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-06     Completed Date:  2007-05-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1050-6     Citation Subset:  AIM; IM    
Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH, USA.
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Chromatography, High Pressure Liquid
Flavonoids / pharmacokinetics,  urine
Gas Chromatography-Mass Spectrometry
Glucosides / pharmacokinetics*,  urine
Intestinal Absorption*
Intestine, Small / metabolism*
Isoflavones / pharmacokinetics*,  urine
Middle Aged
Soy Foods*
beta-Glucans / pharmacokinetics,  urine
Reg. No./Substance:
0/Flavonoids; 0/Glucosides; 0/Isoflavones; 0/beta-Glucans; 0/soy isoflavone aglycone

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