| Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. | |
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MedLine Citation:
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PMID: 12714433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was undertaken to address the vascular effects of isolated isoflavones as potential contributors to their cardioprotective properties, focusing on biochanin and formononetin. METHODS AND RESULTS: In a randomized, double-blind trial, 80 healthy subjects, 46 men and 34 women, 45 to 75 years of age, received isoflavones enriched in either biochanin or formononetin (precursors of genistein and daidzein; 80 mg/d) crossed over randomly with placebo in two 6-week periods. The end points were measured at baseline and after each intervention and included large artery stiffness (systemic arterial compliance and pulse wave velocity), endothelial function in conduit arteries (flow-mediated vasodilation), 24-hour ambulatory blood pressure, and total peripheral resistance. Isoflavone intervention significantly reduced arterial stiffness with improved systemic arterial compliance (P=0.04; repeated-measures ANOVA, Bonferroni correction) attributable to a reduction in total peripheral resistance (P=0.03) and a corresponding reduction in central pulse wave velocity (P=0.02) compared with placebo. Isoflavones did not affect blood pressure (P=0.5) or flow-mediated vasodilation (P=0.44). Improvements seemed limited to formononetin-enriched isoflavones (adjusted P=0.06). Formononetin treatment also reduced circulating vascular adhesion cell molecule-1 (P<0.01). CONCLUSIONS: In normotensive men and postmenopausal women, red clover isoflavones enriched in formononetin reduced arterial stiffness and total vascular resistance but had no effect on blood pressure. These effects may partly explain the lower cardiovascular risk in populations eating isoflavone-rich diets. |
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Authors:
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Helena J Teede; Barry P McGrath; Lakmini DeSilva; Marja Cehun; Andriana Fassoulakis; Paul J Nestel |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2003-04-24 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 23 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-16 Completed Date: 2004-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1066-71 Citation Subset: IM |
Affiliation:
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Vascular Research Group, Department of Medicine, Monash University, Clayton, Australia. h.teede@southernhealth.org.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arm / blood supply Blood Pressure / drug effects* Cross-Over Studies Diet Double-Blind Method Endothelium, Vascular / drug effects*, physiology Female Genistein / pharmacology Humans Isoflavones / pharmacology* Male Middle Aged Phytoestrogens Plant Preparations / pharmacology* Postmenopause Reference Values Regional Blood Flow Trifolium / chemistry* Vascular Cell Adhesion Molecule-1 / blood Vascular Resistance / drug effects* Vasodilation |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 0/Phytoestrogens; 0/Plant Preparations; 0/Vascular Cell Adhesion Molecule-1; 446-72-0/Genistein; 485-72-3/formononetin; 491-80-5/biochanin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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