Document Detail

Isoflavone reduces body weight by decreasing food intake in ovariectomized rats.
MedLine Citation:
PMID:  19420908     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: The primary objective of this study was to further determine the mechanisms by which isoflavone prevents obesity induced by ovariectomy. METHODS: Female 8-week-old Wistar rats were randomly assigned to 6 groups: a sham-operated group; an ovariectomized (OVX) control group; 3 OVX groups orally administered 400 ppm (L-SI), 1,200 ppm (M-SI) and 3,600 ppm (H-SI) of an isoflavone preparation, respectively, and an OVX group receiving 0.45 ppm of diethylstilbestrol. All animals were allowed free access to a high-fat diet and water for 4 weeks. Some neuropeptides, including ghrelin, neuropeptide Y (NPY), alpha-melanocyte-stimulating hormone (alpha-MSH), cholecystokinin (CCK), peptide YY (PYY), insulin and estradiol (E2), were measured by radioimmunoassay. RESULTS: Compared with the OVX control group, body weight, total abdominal fat, food intake and food availability of the M-SI and H-SI groups were significantly reduced. The results also showed that isoflavone and diethylstilbestrol could decrease ghrelin and NPY levels and increase CCK, PYY and E2 levels. The level of alpha-MSH was not changed. CONCLUSIONS: These findings showed that isoflavone could reduce obesity by decreasing food intake, possibly by (1) reducing ghrelin and NPY levels, thereby decreasing food intake, and (2) increasing CCK and PYY levels, which can induce satiety by irritating the vagal center.
Yunbo Zhang; Xiaolin Na; Yang Zhang; Lina Li; Xinyu Zhao; Hongbin Cui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-06
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  54     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2009  
Date Detail:
Created Date:  2009-08-06     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  163-70     Citation Subset:  IM    
Copyright Information:
2009 S. Karger AG, Basel.
Department of Food Nutrition and Hygiene, Public Health College, Harbin Medical University, Harbin, China.
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MeSH Terms
Adipose Tissue
Analysis of Variance
Body Weight*
Dietary Fats / administration & dosage
Diethylstilbestrol / administration & dosage,  metabolism
Energy Metabolism / physiology
Estradiol / blood
Isoflavones / administration & dosage*,  metabolism
Neuropeptides / blood
Obesity / prevention & control
Organ Size
Peptide Hormones / blood
Random Allocation
Rats, Wistar
Soybeans / chemistry*
Reg. No./Substance:
0/Dietary Fats; 0/Isoflavones; 0/Neuropeptides; 0/Peptide Hormones; 50-28-2/Estradiol; 56-53-1/Diethylstilbestrol

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