Document Detail


Isoflavone profile and biological activity of soy bread.
MedLine Citation:
PMID:  14664516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examines the ability of isoflavone extracts from whole soy bread and two soy bread fractions, crumb and crust, to modulate the proliferation of human prostate cancer PC-3 cells. Total isoflavone content in the two fractions of soy bread were similar (3.17 micromol/g dry basis). However, their conjugate patterns were altered. Both fractions of soy bread contained a similar level of isoflavone aglycones ( approximately 24%). Low concentrations of soy bread extracts increased PC-3 cell proliferation as much as 47% compared to untreated control. This proliferative effect in cell growth was reduced at higher extract concentration. Soy bread crust extract (10 mg/mL) reduced PC-3 cell proliferation by 15% compared to untreated control. Interestingly, wheat bread extracts increased cell proliferation at all concentrations tested. Although extracts from both breads possessed biological activity, only soy bread crust extract reduced PC-3 cell proliferation. This observation may be related to the presence of soy in this bread.
Authors:
Yu Chu Zhang; Daniel Albrecht; Joshua Bomser; Steven J Schwartz; Yael Vodovotz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  51     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-10     Completed Date:  2004-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7611-6     Citation Subset:  IM    
Affiliation:
Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210, USA.
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MeSH Terms
Descriptor/Qualifier:
Bread / analysis*
Cell Division / drug effects
Humans
Isoflavones / analysis*,  pharmacology*
Male
Prostatic Neoplasms / pathology
Soy Foods / analysis*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Isoflavones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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