Document Detail

Isoflavone profile and biological activity of soy bread.
MedLine Citation:
PMID:  14664516     Owner:  NLM     Status:  MEDLINE    
The present study examines the ability of isoflavone extracts from whole soy bread and two soy bread fractions, crumb and crust, to modulate the proliferation of human prostate cancer PC-3 cells. Total isoflavone content in the two fractions of soy bread were similar (3.17 micromol/g dry basis). However, their conjugate patterns were altered. Both fractions of soy bread contained a similar level of isoflavone aglycones ( approximately 24%). Low concentrations of soy bread extracts increased PC-3 cell proliferation as much as 47% compared to untreated control. This proliferative effect in cell growth was reduced at higher extract concentration. Soy bread crust extract (10 mg/mL) reduced PC-3 cell proliferation by 15% compared to untreated control. Interestingly, wheat bread extracts increased cell proliferation at all concentrations tested. Although extracts from both breads possessed biological activity, only soy bread crust extract reduced PC-3 cell proliferation. This observation may be related to the presence of soy in this bread.
Yu Chu Zhang; Daniel Albrecht; Joshua Bomser; Steven J Schwartz; Yael Vodovotz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  51     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-10     Completed Date:  2004-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7611-6     Citation Subset:  IM    
Department of Food Science and Technology, The Ohio State University, Columbus, Ohio 43210, USA.
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MeSH Terms
Bread / analysis*
Cell Division / drug effects
Isoflavones / analysis*,  pharmacology*
Prostatic Neoplasms / pathology
Soy Foods / analysis*
Tumor Cells, Cultured
Reg. No./Substance:

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