Document Detail


Isoenzyme spectrum of creatine kinase and lactate dehydrogenase in the myocardium of patients with ischaemic heart disease.
MedLine Citation:
PMID:  3792005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the study was to find out the character of the restructuring of enzymes and isoenzymes of creatine kinase (CK), lactate dehydrogenase (LDH) and glucose-6-phosphate-dehydrogenase (G 6 P-DH) in the myocardium, which occurs in patients with ischaemic heart disease (IHD), and to compare the activity of the aforementioned enzymes in the myocardium of patients with IHD, examined intra vitam, and in patients who died suddenly. An analysis was made of 11 samples obtained by myocardial biopsy from the left ventricle of patients with IHD and of 11 samples obtained at autopsy of patients with IHD who have died a sudden death. Serving as controls was bioptic material from the myocardium of 12 patients without IHD. In the myocardium of patients with IHD, examined intra vitam, a decrease in the activity of the mitochondrial isoenzyme CK (MiMi) and the isoenzyme LDH-1, and a considerable rise in the activity of G 6 P-DH were found. In patients with IHD, who have died suddenly, there was found only a decrease in isoenzyme LDH-1 activity and a reduced concentration of CK B-units. The experiments proved that the differences in the myocardial isoenzyme spectrum between the two groups of patients with IHD are not connected with the process of autolysis.
Authors:
V V Avilov; D B Saprygin; E N Kazakov; I E Galakhov; V S Zhdanov
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  28     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-17     Completed Date:  1987-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  334-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Coronary Disease / complications,  enzymology*
Creatine Kinase / metabolism*
Death, Sudden / etiology
Glucosephosphate Dehydrogenase / metabolism
Humans
Isoenzymes
L-Lactate Dehydrogenase / metabolism*
Male
Middle Aged
Mitochondria, Heart / enzymology
Myocardium / enzymology*
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.1.1.49/Glucosephosphate Dehydrogenase; EC 2.7.3.2/Creatine Kinase

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