Document Detail


Isochromosomes in childhood acute lymphoblastic leukemia: a collaborative study of 83 cases.
MedLine Citation:
PMID:  1571550     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cytogenetic analysis of leukemic cells from 2,805 children with newly diagnosed acute lymphoblastic leukemia (ALL) identified 83 cases (3%) that had a stemline with at least one isochromosome. The i(9q) was present in 28 (1%), the i(17q) in 23 (0.8%), and the i(7q) in 23 (0.8%). Other isochromosomes--i(21q), i(6p), i(1q), i(8q), or i(Xq)--were found in only 12 cases (0.4%). The isochromosome cases were more likely than were other ALL cases to have a pre-B immunophenotype (38% v 25%, P = .02) and leukemic cell hyperdiploidy greater than 50 (37% v 24%, P = .02); five cases had both features. The i(9q) was associated with age greater than 10 years (P less than .05) and the pre-B immunophenotype (P = .05); both the i(17q) and i(7q) had high frequencies of hyperdiploidy greater than 50 (P less than .0001 and P = .05, respectively). The t(1;19)(q23;p13) was a common feature (23%) in cases with the i(9q), i(7q), i(6p), or i(1q). These findings establish the i(9q), i(17q), and i(7q) as nonrandom chromosomal abnormalities in ALL. The prognostic significance of the presence of isochromosome(s) remains to be determined.
Authors:
C H Pui; A J Carroll; S C Raimondi; M J Schell; D R Head; J J Shuster; W M Crist; M J Borowitz; M P Link; F G Behm
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  79     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-05-29     Completed Date:  1992-05-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2384-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Hematology-Oncology, St Jude Children's Research Hospital, Memphis, TN 38101.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Chromosome Aberrations*
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 9
Female
Humans
Infant
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Grant Support
ID/Acronym/Agency:
CA-20180/CA/NCI NIH HHS; CA-21765/CA/NCI NIH HHS; CA-31566/CA/NCI NIH HHS

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