Document Detail

Isocapnic hyperpnoea shortens postanesthetic care unit stay after isoflurane anesthesia.
MedLine Citation:
PMID:  20495141     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We conducted a prospective controlled clinical trial of the effect of isocapnic hyperpnoea (IH) on the times-to-recovery milestones in the operating room (OR) and postanesthetic care unit (PACU) after 1.5 to 3 hours of isoflurane anesthesia. METHODS: Thirty ASA grade I-III patients undergoing elective gynecological surgery were randomized at the end of surgery to either IH or the conventional recovery (control). Six patients with duration of anesthesia of <90 minutes were excluded from the analysis. The anesthesia protocol included propofol, fentanyl, morphine, rocuronium, and isoflurane in air/O(2). Unpaired t tests and analyses of variance were used to test for differences in times-to-recovery indicators between the two groups. RESULTS: The durations of anesthesia in IH and control groups were 140.8 + or - 32.7 and 142 + or - 55.6 minutes, respectively (P = 0.99). The time to extubation was much shorter in the IH group than in the control group (6.6 + or - 1.6 (SD) vs. 13. 6 + or - 3.9 minutes, respectively; P < 0.01). The IH group also had shorter times to eye opening (5.8 + or - 1.3 vs. 13.7 + or - 4.5 minutes; P < 0.01), eligibility for leaving the OR (8.0 + or - 1.7 vs. 17.4 + or - 6.1 minutes; P < 0.01), and eligibility for PACU discharge (74.0 + or - 16.5 vs. 94.5 + or - 14.7 minutes; P < 0.01). There were no differences in other indicators of recovery. CONCLUSION: IH accelerates recovery after 1.5 to 3 hours of isoflurane anesthesia and shortens OR and PACU stay.
Rita Katznelson; Adriaan Van Rensburg; Zeev Friedman; Marcin Wasowicz; George N Djaiani; Ludwik Fedorko; Leonid Minkovich; Joseph A Fisher
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-05-21
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  111     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-28     Completed Date:  2010-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-8     Citation Subset:  AIM; IM    
Department of Anesthesia, Toronto General Hospital, Eaton North 3-453, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada. rita.katznelson@uhn.on.c
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MeSH Terms
Anesthesia Recovery Period*
Anesthetics, Inhalation*
Gynecologic Surgical Procedures
Length of Stay*
Middle Aged
Operating Rooms
Prospective Studies
Recovery Room*
Surgical Procedures, Elective
Time Factors
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane

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