Document Detail


Isobaric intestinal distension in humans: sensorial relay and reflex gastric relaxation.
MedLine Citation:
PMID:  2305885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the relationship between perception of segmental intestinal distension and the reflex gastric tone response, we performed in eight healthy volunteers graded isobaric distensions (2.5 min duration at 10 min intervals) of the duodenum and the jejunum using an electronic barostat. We measured gastric tone as intragastric air volume by a separate barostat and the perception score by a graded questionnaire. At the threshold distending pressure for discomfort in the duodenum (23 +/- 2 mmHg), both perception (5.7 +/- 0.2 score; P less than 0.01) and reflex gastric relaxation (148 +/- 35 ml delta gastric vol; P less than 0.01) were elicited. Lower pressures (12 mmHg below the discomfort threshold) failed to produce perception (0.6 +/- 0.4 score), but significant relaxation was still induced (63 +/- 22 ml delta gastric vol; P less than 0.05). In contrast, no significant gastric relaxation occurred at any pressure level tested in the jejunum (up to 27 +/- 2 mmHg), whereas the perception scores paralleled those produced by duodenal distension. This dissociation between symptoms and visceral reflexes suggests that both responses are independently induced by specific mechanisms.
Authors:
F Azpiroz; J R Malagelada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  258     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-03-28     Completed Date:  1990-03-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G202-7     Citation Subset:  IM    
Affiliation:
Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Heart Rate
Humans
Intestines / physiology*
Male
Models, Biological
Muscle Contraction*
Muscle Relaxation
Muscle, Smooth / physiology*
Perception
Pressoreceptors / physiology
Pressure
Reflex*
Stomach / physiopathology*
Grant Support
ID/Acronym/Agency:
AM-26428/AM/NIADDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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