| Islet organogenesis, angiogenesis and innervation. | |
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MedLine Citation:
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PMID: 21999312 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The pancreas is characterized by a major component, an exocrine and ductal system involved in digestion, and a minor component, the endocrine islets represented by islet micro-organs that tightly regulate glucose homoeostasis. Pancreatic organogenesis is strictly co-ordinated by transcription factors that are expressed sequentially to yield functional islets capable of maintaining glucose homoeostasis. Angiogenesis and innervation complete islet development, equipping islets to respond to metabolic demands. Proper regulation of this triad of processes during development is critical for establishing functional islets. |
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Authors:
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Marlon E Cerf |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell biology international Volume: 35 ISSN: 1095-8355 ISO Abbreviation: Cell Biol. Int. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
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Languages: eng Pagination: 1065-78 Citation Subset: IM |
Affiliation:
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Diabetes Discovery Platform, South African Medical Research Council, PO Box 19070, Tygerberg, 7505 Cape Town, South Africa. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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