| Islet hyperperfusion during prediabetic phase in OLETF rats, a model of type 2 diabetes. | |
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MedLine Citation:
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PMID: 12145167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it has been hypothesized that initial hyperperfusion followed by late hypoperfusion in islet circulation occurs in rodent models of type 2 diabetes, islet blood flow has not been measured during prediabetic phase. We studied islet blood flow in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of slowly progressive obese type 2 diabetes. Islet blood flow was measured by the two-color microsphere method under anesthesia at different ages. Islet blood flow was significantly higher in young OLETF rats compared with control Long-Evans Tokushima Otsuka (LETO) rats when the former were not obese or diabetic and had normal insulin secretion at 5 weeks of age (LETO 4.6 +/- 1.1, OLETF 8.8 +/- 1.2 ml. min(-1). mg(- 1), P < 0.01). At 6 months of age, islet hyperperfusion was observed in OLETF rats, and >40% of whole pancreatic blood flow was diverted into islets in OLETF rats. Prevention of obesity by food restriction increased basal islet blood flow. On the other hand, long-term hyperglycemia induced by sucrose feeding decreased fractional islet blood flow as well as glucose-stimulated islet blood flow. Our results indicate that hyperperfusion is present during the preobese and prediabetic phase in our type 2 diabetes rats. |
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Authors:
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Masanori Iwase; Yuji Uchizono; Kenji Tashiro; Daisuke Goto; Mitsuo Iida |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes Volume: 51 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-29 Completed Date: 2002-08-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 2530-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. iwase@intmed2.med.kyushu-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diabetes Mellitus, Type 2 / physiopathology* Diet, Reducing Dietary Sucrose / pharmacology Disease Models, Animal Insulin / blood* Islets of Langerhans / blood supply, drug effects, physiopathology* Male Pancreas / blood supply Perfusion Prediabetic State / physiopathology* Rats Rats, Inbred OLETF Rats, Long-Evans Regional Blood Flow / drug effects Species Specificity omega-N-Methylarginine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Dietary Sucrose; 11061-68-0/Insulin; 17035-90-4/omega-N-Methylarginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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