| Islet cell hormonal responses to hypoglycemia after human islet transplantation for type 1 diabetes. | |
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MedLine Citation:
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PMID: 16249446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Islet transplantation can eliminate severe hypoglycemic episodes in patients with type 1 diabetes; however, whether intrahepatic islets respond appropriately to hypoglycemia after transplantation has not been fully studied. We evaluated six islet transplant recipients, six type 1 diabetic subjects, and seven nondiabetic control subjects using a stepped hyperinsulinemic-hypoglycemic clamp. Also, three islet transplant recipients and the seven control subjects underwent a paired hyperinsulinemic-euglycemic clamp. In response to hypoglycemia, C-peptide was similarly suppressed in islet transplant recipients and control subjects and was not detectable in type 1 diabetic subjects. Glucagon was significantly more suppressed in type 1 diabetic subjects than in islet transplant recipients (P < 0.01), although the glucagon in islet transplant recipients failed to activate as in the control subjects (P < 0.01). Pancreatic polypeptide failed to activate in both type 1 diabetic subjects and islet transplant recipients compared with control subjects (P < 0.01). In islet transplant recipients, glucagon was suppressed normally by hyperinsulinemia during the euglycemic clamp and was significantly greater during the paired hypoglycemic clamp (P < 0.01). These results suggest that after islet transplantation and in response to insulin-induced hypoglycemia, endogenous insulin secretion is appropriately suppressed and glucagon secretion may be partially restored. |
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Authors:
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Michael R Rickels; Mark H Schutta; Rebecca Mueller; James F Markmann; Clyde F Barker; Ali Naji; Karen L Teff |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes Volume: 54 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-26 Completed Date: 2006-01-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: United States |
Other Details:
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Languages: eng Pagination: 3205-11 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Diabetes & Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6149, USA. rickels@mail.med.upenn.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose Case-Control Studies Diabetes Mellitus, Type 1 / surgery* Female Glucagon / blood Humans Hypoglycemia / metabolism* Insulin / blood Islets of Langerhans / metabolism* Islets of Langerhans Transplantation* Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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K12-RR017625/RR/NCRR NIH HHS; M01-RR-00040/RR/NCRR NIH HHS; P30-DK-19525/DK/NIDDK NIH HHS; U42-RR-016600/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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