Document Detail

Islet blood flow following insulin administration.
MedLine Citation:
PMID:  2691470     Owner:  NLM     Status:  MEDLINE    
Blood flow to the pancreatic islets of the anaesthetised rat was measured using the microsphere method. Basal flow was 29 (+/- 6) microliter/min per pancreas which was equivalent to 2.1 (+/- 0.2)% of the total pancreatic flow. The intravenous administration of 4 IU of soluble insulin, which rendered the animals hypoglycaemic, selectively increased islet flow to 93 (+/- 19) microliter/min per pancreas, equivalent to 5.4 (+/- 0.2)% of total pancreatic flow. It is suggested that this may be related to an enhanced release of glucagon from the islet A cells in response to the hypoglycaemia. Administration of 2.5 ml of a 25% glucose solution intraperitoneally gave rise to hyperglycaemia and produced a similar preferential increase in islet blood flow to 86 (+/- 25) microliter/min per pancreas, 7.4 (+/- 0.2)% of total pancreatic flow.
R A Sparrow; I J Beckingham
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of anatomy     Volume:  163     ISSN:  0021-8782     ISO Abbreviation:  J. Anat.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1990-02-22     Completed Date:  1990-02-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0137162     Medline TA:  J Anat     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Department of Human Morphology, University of Nottingham Medical School, Queen's Medical Centre.
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MeSH Terms
Blood Flow Velocity / drug effects,  physiology
Hypoglycemia / chemically induced,  physiopathology
Injections, Intravenous
Insulin / administration & dosage,  pharmacology*
Islets of Langerhans / blood supply,  physiology*
Rats, Inbred Strains
Reg. No./Substance:

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