| Islet blood flow following insulin administration. | |
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MedLine Citation:
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PMID: 2691470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood flow to the pancreatic islets of the anaesthetised rat was measured using the microsphere method. Basal flow was 29 (+/- 6) microliter/min per pancreas which was equivalent to 2.1 (+/- 0.2)% of the total pancreatic flow. The intravenous administration of 4 IU of soluble insulin, which rendered the animals hypoglycaemic, selectively increased islet flow to 93 (+/- 19) microliter/min per pancreas, equivalent to 5.4 (+/- 0.2)% of total pancreatic flow. It is suggested that this may be related to an enhanced release of glucagon from the islet A cells in response to the hypoglycaemia. Administration of 2.5 ml of a 25% glucose solution intraperitoneally gave rise to hyperglycaemia and produced a similar preferential increase in islet blood flow to 86 (+/- 25) microliter/min per pancreas, 7.4 (+/- 0.2)% of total pancreatic flow. |
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Authors:
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R A Sparrow; I J Beckingham |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of anatomy Volume: 163 ISSN: 0021-8782 ISO Abbreviation: J. Anat. Publication Date: 1989 Apr |
Date Detail:
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Created Date: 1990-02-22 Completed Date: 1990-02-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0137162 Medline TA: J Anat Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 75-81 Citation Subset: IM |
Affiliation:
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Department of Human Morphology, University of Nottingham Medical School, Queen's Medical Centre. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects, physiology Hypoglycemia / chemically induced, physiopathology Injections, Intravenous Insulin / administration & dosage, pharmacology* Islets of Langerhans / blood supply, physiology* Male Microspheres Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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