Document Detail


Islet amyloid polypeptide--hen or egg in type 2 diabetes pathogenesis?
MedLine Citation:
PMID:  8323756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Islet amyloid polypeptide (IAPP or amylin) was first identified as the major peptide constituent of amyloid deposited in the islets of Langerhans in patients with type-2 diabetes mellitus or in insulinomas. It was subsequently shown that IAPP is produced by the pancreatic beta-cells, co-stored and co-released with insulin. IAPP is homologous with the neuropeptide calcitonin gene-related peptide (CGRP) and has therefore been assumed to have a function as an endocrine, paracrine or autocrine hormone. This has prompted the search for its physiological function as well as a putative pathogenic role in type 2 diabetes mellitus.
Authors:
C Betsholtz; L Christmanson; S Gebre-Medhin; P Westermark
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  32     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1993  
Date Detail:
Created Date:  1993-08-10     Completed Date:  1993-08-10     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Uppsala, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Amyloid / genetics,  physiology*
Animals
Diabetes Mellitus, Type 2 / etiology*,  genetics
Humans
Chemical
Reg. No./Substance:
0/Amyloid; 106602-62-4/amylin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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