| Islet NADPH oxidase activity is modulated unevenly by different secretagogues. | |
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MedLine Citation:
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PMID: 20972732 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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NADPH oxidase expression and activity have been measured in pancreatic islets under normal conditions, but its potential modulatory role upon insulin secretion remains unclear. We have currently studied NADPH oxidase activity in islets isolated from normal rats as well as the effect of its inhibition upon insulin secretion stimulated by different secretagogues. Glucose, arginine, fatty acids and KCl increased islet NADPH oxidase activity in a stimulus-dependent manner. DPI inhibited such increase in different proportions and affected unevenly insulin secretion, namely, it decreased the effect of high glucose, increased that of oleic acid and KCl, without changing the one induced by palmitic acid. Our data provide evidence that the contribution of NADPH activity to reactive oxygen species production in normal rat islets as well as its effect upon insulin secretion is uneven and highly stimulus-dependent. |
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Authors:
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Oscar R Rebolledo; María A Raschia; María I Borelli; María E García; Juan J Gagliardino |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-23 |
Journal Detail:
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Title: Endocrine Volume: 38 ISSN: 1559-0100 ISO Abbreviation: Endocrine Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434444 Medline TA: Endocrine Country: United States |
Other Details:
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Languages: eng Pagination: 309-11 Citation Subset: IM |
Affiliation:
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CENEXA (UNLP-CONICET LA PLATA, PAHO/WHO Collaborating Center), School of Medical Sciences, Facultad de Ciencias Médicas UNLP, Calles 60 y 120, 1900, La Plata, Argentina. |
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