| Isl1 is required for multiple aspects of motor neuron development. | |
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MedLine Citation:
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PMID: 21569850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The LIM homeodomain transcription factor Islet1 (Isl1) is expressed in multiple organs and plays essential roles during embryogenesis. Isl1 is required for the survival and specification of spinal cord motor neurons. Due to early embryonic lethality and loss of motor neurons, the role of Isl1 in other aspects of motor neuron development remains unclear. In this study, we generated Isl1 mutant mouse lines expressing graded doses of Isl1. Our study has revealed essential roles of Isl1 in multiple aspects of motor neuron development, including motor neuron cell body localization, motor column formation and axon growth. In addition, Isl1 is required for survival of cranial ganglia neurons. |
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Authors:
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Xingqun Liang; Mi-Ryoung Song; ZengGuang Xu; Guillermo M Lanuza; Yali Liu; Tao Zhuang; Yihan Chen; Samuel L Pfaff; Sylvia M Evans; Yunfu Sun |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-05-04 |
Journal Detail:
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Title: Molecular and cellular neurosciences Volume: 47 ISSN: 1095-9327 ISO Abbreviation: Mol. Cell. Neurosci. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-03 Completed Date: 2011-10-07 Revised Date: 2013-06-12 |
Medline Journal Info:
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Nlm Unique ID: 9100095 Medline TA: Mol Cell Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 215-22 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Key Laboratory of Arrhythmia, Ministry of Education, East Hospital, Tongji University School of Medicine, Shanghai 200120, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / metabolism Embryonic Development / physiology* Homeodomain Proteins / genetics, metabolism* LIM-Homeodomain Proteins Mice Mice, Transgenic Motor Neurons / metabolism* Spinal Cord / embryology, metabolism* Transcription Factors |
| Grant Support | |
ID/Acronym/Agency:
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5R01HL070867-04/HL/NHLBI NIH HHS; R01 NS037116-06A1/NS/NINDS NIH HHS; R01 NS037116-07/NS/NINDS NIH HHS; R01 NS037116-07S1/NS/NINDS NIH HHS; R01 NS037116-08/NS/NINDS NIH HHS; R01 NS037116-08S1/NS/NINDS NIH HHS; R01 NS037116-09/NS/NINDS NIH HHS; R01 NS037116-10/NS/NINDS NIH HHS; R01 NS054172-01A2/NS/NINDS NIH HHS; R01 NS054172-02/NS/NINDS NIH HHS; R01 NS054172-03/NS/NINDS NIH HHS; R01 NS054172-04/NS/NINDS NIH HHS; R01 NS054172-05/NS/NINDS NIH HHS; R37 NS037116/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Homeodomain Proteins; 0/LIM-Homeodomain Proteins; 0/Transcription Factors; 0/insulin gene enhancer binding protein Isl-1 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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