Document Detail


Ischemic stroke in elderly patients treated with a free radical scavenger-glycolytic intermediate solution: a preliminary pilot trial.
MedLine Citation:
PMID:  11783757     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The safety and tolerability of a free radical scavenger with Na+ channel blocking activity (dimethyl sulfoxide (DMSO)) combined with a glycolytic intermediate and high energy substrate (fructose 1,6-disphosphate (FDP)) were assessed in a mostly elderly patient group presenting with acute and subacute ischemic stroke. Eleven patients (average age 65) were given i.v. infusions of DMSO-FDP twice daily for an average of 12 days, while five control patients (average age 63) were given standard therapy. Safety and tolerability were evaluated by clinical adverse effects to drug therapy. Efficacy of DMSO-FDP was assessed by MRI lesion size, by magnetic resonance angiography of ischemic territory, and by a 5-point neurologic recovery scale that rated sensory-motor function and level of consciousness. Results suggest that DMSO-FDP administration is safe, well-tolerated and may be of benefit when given within 12 h after the onset of stroke symptoms. No significant changes in blood pressure, EKG, heart rate or hematology and chemistry profiles, were recorded in any patient receiving DMSO-FDP. Neurologic evaluation at 1, 3 and 6 months after treatments revealed that 7 of 11 (63%) patients given DMSO-FDP achieved 'improved' or 'markedly improved' status while 1 of 5 (20%) standard treated patients showed 'improved' status and only at the 3-month follow-up. This preliminary trial indicates that DMSO-FDP is well tolerated by this group of elderly patients and could be of benefit in reducing neurologic disability after stroke.
Authors:
Mustafa Karaça; Erol Kiliç; Betül Yazici; Sedat Demir; Jack C de la Torre
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  24     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-09     Completed Date:  2002-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Ihlas Medical Center, Bursa, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging / drug effects*,  metabolism
Brain / drug effects,  pathology,  physiopathology
Brain Edema / drug therapy,  physiopathology,  prevention & control
Cerebrovascular Circulation / drug effects,  physiology
Dimethyl Sulfoxide / adverse effects,  therapeutic use*
Drug Combinations
Female
Free Radical Scavengers / adverse effects,  therapeutic use*
Fructosediphosphates / adverse effects,  therapeutic use*
Humans
Hypoxia-Ischemia, Brain / drug therapy*,  metabolism,  physiopathology
Infarction, Middle Cerebral Artery / drug therapy,  pathology,  prevention & control
Male
Middle Aged
Middle Cerebral Artery / pathology,  physiopathology
Nerve Degeneration / drug therapy,  physiopathology,  prevention & control
Neuroprotective Agents / adverse effects,  therapeutic use*
Sodium Channels / drug effects,  metabolism
Stroke / drug therapy*,  metabolism,  physiopathology
Survival Rate
Treatment Outcome
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Free Radical Scavengers; 0/Fructosediphosphates; 0/Neuroprotective Agents; 0/Sodium Channels; 488-69-7/fructose-1,6-diphosphate; 67-68-5/Dimethyl Sulfoxide

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