| Ischemic preconditioning suppresses ventricular tachyarrhythmias after myocardial revascularization. | |
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MedLine Citation:
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PMID: 12473557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ventricular fibrillation (VF) and tachycardia (VT) are the common and potential life-threatening complications after CABG. Ischemic preconditioning (IP) has been proved effective in reducing ischemia reperfusion arrhythmia in animals and humans. Whether IP is effective in suppressing postoperative VF/VT in patients with CABG has not been studied. METHODS AND RESULTS: Eighty-six patients with CABG with stable and unstable 3-vessel disease were equally randomly assigned into an IP and a control group. The patients who received IP received 2 periods of 2-minute ischemia followed by 3-minute reperfusion. Twenty-four-hour electrocardiographic data were collected. IP resulted in fewer cases of VF after declamping (48.8% versus 79.1% in IP and control, P=0.004) and a shorter VF period (2.28+/-0.44 versus 4.41+/-0.51 minutes, P=0.002). The episodes of VT were significantly reduced in patients in the IP group during early reperfusion and 24 hours after reperfusion (0.65+/-0.16 versus 3.71+/-0.46, P=0.000 and 0.07+/-0.04 versus 2.12+/-1.41, P=0.002, respectively). De novo sustained VT occurred in 3 control patients as against none in the IP group after surgery. As a result, IP significantly curtailed the mechanical ventilation period and reduced the need for inotropes. CONCLUSIONS: IP significantly reduced postoperative VF/VT in patients with CABG with 3-vessel disease. Suppression of VT during early reperfusion and 24 hours after reperfusion suggests early and delayed IP phenomena in patients undergoing CABG surgery. |
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Authors:
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Zhong-Kai Wu; Tiina Iivainen; Erkki Pehkonen; Jari Laurikka; Matti R Tarkka |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 106 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-10 Completed Date: 2002-12-17 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 3091-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiac Surgery, Department of Surgery, Tampere University Hospital, Tampere, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Coronary Artery Bypass* / adverse effects Coronary Artery Disease / surgery Electrocardiography, Ambulatory Female Heart Rate Humans Ischemic Preconditioning, Myocardial* Male Middle Aged Myocardial Revascularization* / adverse effects Tachycardia, Ventricular / etiology, prevention & control* Treatment Outcome Ventricular Fibrillation / etiology, prevention & control* |
| Comments/Corrections | |
Comment In:
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Circulation. 2002 Dec 10;106(24):2999-3001
[PMID:
12473541
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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