Document Detail


Ischemic preconditioning and clinical scenarios.
MedLine Citation:
PMID:  23197083     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Ischemic preconditioning (IPC) is gaining attention as a novel neuroprotective therapy and could provide an improved mechanistic understanding of tolerance to cerebral ischemia. The purpose of this article is to review the recent work in the field of IPC and its applications to clinical scenarios.
RECENT FINDINGS: The cellular signaling pathways that are activated following IPC are now better understood and have enabled investigators to identify several IPC mimetics. Most of these studies were performed in rodents, and efficacy of these mimetics remains to be evaluated in human patients. Additionally, remote ischemic preconditioning (RIPC) may have higher translational value than IPC. Repeated cycles of temporary ischemia in a remote organ can activate protective pathways in the target organ, including the heart and brain. Clinical trials are underway to test the efficacy of RIPC in protecting brain against subarachnoid hemorrhage.
SUMMARY: IPC, RIPC, and IPC mimetics have the potential to be therapeutic in various clinical scenarios. Further understanding of IPC-induced neuroprotection pathways and utilization of clinically relevant animal models are necessary to increase the translational potential of IPC in the near future.
Authors:
Srinivasan V Narayanan; Kunjan R Dave; Miguel A Perez-Pinzon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  26     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-10     Completed Date:  2013-06-25     Revised Date:  2013-08-28    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, Cerebral Vascular Disease Research Center, University of Miami, Miller School of Medicine, Miami, Florida, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Ischemia / prevention & control*
Disease Models, Animal
Humans
Ischemic Preconditioning*
Organelles / physiology
Oxidative Stress / physiology
Signal Transduction / physiology
Grant Support
ID/Acronym/Agency:
F31 NS080344/NS/NINDS NIH HHS; F31 NS080344-01/NS/NINDS NIH HHS; NS054147/NS/NINDS NIH HHS; NS073779/NS/NINDS NIH HHS; NS34773/NS/NINDS NIH HHS; NS45676/NS/NINDS NIH HHS; R01 NS045676/NS/NINDS NIH HHS; R01 NS054147/NS/NINDS NIH HHS; R01 NS073779/NS/NINDS NIH HHS; R29 NS034773/NS/NINDS NIH HHS
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