Document Detail

Ischemic postconditioning as a novel avenue to protect against brain injury after stroke.
MedLine Citation:
PMID:  19240739     Owner:  NLM     Status:  MEDLINE    
Ischemic postconditioning initially referred to a stuttering reperfusion performed immediately after reperfusion, for preventing ischemia/reperfusion injury in both myocardial and cerebral infarction. It has evolved into a concept that can be induced by a broad range of stimuli or triggers, and may even be performed as late as 6 h after focal ischemia and 2 days after transient global ischemia. The concept is thought to be derived from ischemic preconditioning or partial/gradual reperfusion, but in fact the first experiment for postconditioning was carried out much earlier than that of preconditioning or partial/gradual reperfusion, in the research on myocardial ischemia. This review first examines the protective effects and parameters of postconditioning in various cerebral ischemic models. Thereafter, it provides insights into the protective mechanisms of postconditioning associated with reperfusion injury and the Akt, mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and ATP-sensitive K+ (K(ATP)) channel cell signaling pathways. Finally, some open issues and future challenges regarding clinical translation of postconditioning are discussed.
Heng Zhao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-02-25
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  29     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-30     Completed Date:  2009-05-15     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  873-85     Citation Subset:  IM    
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305-5327, USA.
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MeSH Terms
Brain / blood supply*,  enzymology,  metabolism
Cerebrovascular Circulation
Ischemic Preconditioning*
Reperfusion Injury / enzymology,  metabolism,  prevention & control*
Stroke / complications,  enzymology,  metabolism,  therapy*
Grant Support
1R21NS057750-01A2/NS/NINDS NIH HHS; R21 NS057750/NS/NINDS NIH HHS; R21 NS057750-01A2/NS/NINDS NIH HHS

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