Document Detail

Ischemic optic neuropathy secondary to intracarotid infusion of BCNU.
MedLine Citation:
PMID:  2956289     Owner:  NLM     Status:  MEDLINE    
A 39-year-old man with a left parietal malignant glioma was treated with intracarotid infusion of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Five weeks after a second infusion, he developed inferior altitudinal visual field loss and pallid optic disc edema ipsilateral to the injection. Retinal vasculitis is a well-recognized complication of intra-arterial BCNU infusion. It is believed that this patient suffered a similar vasculopathy in the posterior ciliary artery circulation.
L Pickrell; V Purvin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical neuro-ophthalmology     Volume:  7     ISSN:  0272-846X     ISO Abbreviation:  J Clin Neuroophthalmol     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-08-31     Completed Date:  1987-08-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109051     Medline TA:  J Clin Neuroophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  87-92     Citation Subset:  IM    
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MeSH Terms
Brain Neoplasms / drug therapy
Carmustine / adverse effects*,  therapeutic use
Carotid Artery, Internal
Fluorescein Angiography
Glioma / drug therapy
Infusions, Intra-Arterial
Ischemia / chemically induced*
Optic Disk / blood supply*
Papilledema / chemically induced*
Visual Fields
Reg. No./Substance:

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