Document Detail

Ischemic mitral regurgitation.
MedLine Citation:
PMID:  16703238     Owner:  NLM     Status:  MEDLINE    
Ischemic mitral regurgitation is the regurgitation seen with structurally normal valve leaflets that occurs in approximately 20% of patients after myocardial infarction and 56% of patients with congestive heart failure caused by ischemic or nonischemic cardiomyopathy. The initiating event is an ischemic insult that results in remodeling of the left ventricle toward a more spherical shape and new wall motion abnormalities. These changes lead to annular dilation and subvalvular distortion that prevent the mitral leaflets from coapting and closing completely during the contraction phase. Treatment options include coronary revascularization, ring annuloplasty, valve repair and replacement, or left ventricle reconstruction by way of localized reshaping or resection. Pharmacotherapy, aimed at raising left ventricular pressure without increasing tethering or left ventricular volume, is included in the treatment options for improving ischemic mitral regurgitation.
Huong Cindy Le; Daniel M Thys
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in cardiothoracic and vascular anesthesia     Volume:  10     ISSN:  1089-2532     ISO Abbreviation:  Semin Cardiothorac Vasc Anesth     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-05-16     Completed Date:  2006-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9807630     Medline TA:  Semin Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  IM    
Department of Anesthesiology, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY, USA.
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MeSH Terms
Mitral Valve / physiopathology
Mitral Valve Insufficiency / classification,  epidemiology,  physiopathology*,  therapy
Myocardial Ischemia / classification,  epidemiology,  physiopathology*
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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