| Ischemic intestinal injury during cardiopulmonary bypass does not show an association with neutrophil activation: a porcine study. | |
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MedLine Citation:
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PMID: 18987476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Neutrophil activation and tissue sequestration are crucial events in intestinal ischemia-reperfusion injury, but their role in the gut wall after clinical cardiopulmonary bypass (CPB) remains unclear. We tested whether local post-CPB inflammatory response in the gut wall would be associated with intestinal mucosal perfusion. METHODS: Twenty pigs underwent 60 min of aortic clamping and 75 min of normothermic perfusion. Intestinal biopsies were taken after 120 min of reperfusion. Based on ileal myeloperoxidase activity (MPO), the animals were divided into 2 groups, CPB-induced increase in MPO (MPO+) versus no such increase (MPO-), for comparison of the parameters that measure gut mucosal perfusion. Ileal p(CO)((2)) and intramucosal pH were determined, and arterial gases were analyzed. Additionally, several hemodynamic parameters and blood thrombin-antithrombin complexes (TAT) were measured. RESULTS: Myocyte degeneration, endothelial activation and vasculitis were more pronounced in the MPO+ group (p < 0.05), while the MPO- group showed significantly increased pi(CO)((2)) and lower mucosal pH values during reperfusion. Hemodynamics and TAT levels did not differ between the groups. CONCLUSION: Tissue sequestration of neutrophils was poorly associated with perturbed mucosal perfusion after CPB. Mechanisms of gut wall injury after a low-flow/reperfusion setting can differ from those in reperfusion injury after total ischemia. |
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Authors:
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M Jormalainen; A E Vento; U Wartiovaara-Kautto; R Suojaranta-Ylinen; J Lauronen; T Paavonen; J Petäjä |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-06 |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 42 ISSN: 1421-9921 ISO Abbreviation: Eur Surg Res Publication Date: 2009 |
Date Detail:
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Created Date: 2008-12-18 Completed Date: 2009-02-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 59-69 Citation Subset: IM |
Copyright Information:
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(c) 2008 S. Karger AG, Basel. |
Affiliation:
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Department of Cardiothoracic Surgery, Helsinki University Central Hospital, Helsinki, Finland. mikko.jormalainen@hus.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiopulmonary Bypass / adverse effects* Female Hemodynamics Hydrogen-Ion Concentration Intestines / blood supply*, enzymology, immunology, injuries* Ischemia / enzymology, etiology*, immunology Male Neutrophil Activation* Peroxidase / metabolism Reperfusion Injury / enzymology, etiology, immunology Sus scrofa |
| Chemical | |
Reg. No./Substance:
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EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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