Document Detail

Ischemic heart disease associated with bortezomib treatment combined with dexamethasone in a patient with multiple myeloma.
MedLine Citation:
PMID:  20458563     Owner:  NLM     Status:  MEDLINE    
A 79-year-old female patient with multiple myeloma who had no prior cardiac disease history developed an acute myocardial infarction on day 5 after receiving bortezomib and dexamethasone (BD). After treatment of coronary stenoses by stents, she received another course of BD therapy and developed angina pectoris on day 5 after the therapy. Bortezomib's antitumor effect is due to the inhibition of proteasome activity. This inhibition may increase endothelial progenitor cell apoptosis and decrease endothelial nitric oxide synthase/nitric oxide (eNOS/NO), thus leading to coronary spasm. It is, therefore, important to carefully monitor patients being treated with bortezomib for the potential occurrence of ischemic heart disease.
Hiroyuki Takamatsu; Takeshi Yamashita; Takeharu Kotani; Aiko Sawazaki; Hirokazu Okumura; Shinji Nakao
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Publication Detail:
Type:  Journal Article     Date:  2010-05-11
Journal Detail:
Title:  International journal of hematology     Volume:  91     ISSN:  1865-3774     ISO Abbreviation:  Int. J. Hematol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111627     Medline TA:  Int J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  903-6     Citation Subset:  IM    
Department of Internal Medicine, NTT WEST Kanazawa Hospital, 6-26 Shimoshinmachi, Kanazawa, Ishikawa, 920-0910, Japan.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Boronic Acids / adverse effects*
Coronary Vessels / drug effects,  pathology
Dexamethasone / adverse effects*
Multiple Myeloma / complications*,  drug therapy*
Myocardial Infarction / chemically induced*
Pyrazines / adverse effects*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Boronic Acids; 0/Pyrazines; 0/bortezomib; 50-02-2/Dexamethasone

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