Document Detail

Ischemic-appearing electrocardiographic changes predict myocardial injury in patients with intracerebral hemorrhage.
MedLine Citation:
PMID:  21450435     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Myocardial injury is common among patients with intracerebral hemorrhage (ICH). However, it is challenging for emergency physicians to recognize acute myocardial injury in this population, as electrocardiographic (ECG) abnormalities are common in this setting. Our objective is to examine whether ischemic-appearing ECG changes predict subsequent myocardial injury in the context of ICH.
METHODS: Consecutive patients with primary ICH presenting to a single academic center were prospectively enrolled. Electrocardiograms were retrospectively reviewed by 3 independent readers. Anatomical areas of ischemia were defined as I and aVL; II, III, and aVF; V(1) to V(4); and V(5) and V(6). Medical record review identified myocardial injury, defined as troponin I or T elevation (cutoff 1.5 and 0.1 ng/mL, respectively), within 30 days.
RESULTS: Between 1998 and 2004, 218 patients presented directly to our emergency department and did not have a do-not-resuscitate/do-not-intubate order; arrival ECGs and troponin levels were available for 206 patients. Ischemic-appearing changes were noted in 41% of patients, and myocardial injury was noted in 12% of patients. Ischemic-appearing changes were more common in patients with subsequent injury (64% vs 37%; P = .02). After multivariable analysis controlling for age and cardiac risk factors, ischemic-appearing ECG changes independently predicted myocardial injury (odds ratio, 3.2; 95% confidence interval, 1.3-8.2). In an exploratory analysis, ischemic-appearing ECG changes in leads I and aVL as well as V(5) and V(6) were more specific for myocardial injury (P = .002 and P = .03, respectively).
CONCLUSION: In conclusion, although a range of ECG abnormalities can occur after ICH, the finding of ischemic-appearing changes in an anatomical distribution can help predict which patients are having true myocardial injury.
Kohei Hasegawa; Megan L Fix; Lauren Wendell; Kristin Schwab; Hakan Ay; Eric E Smith; Steven M Greenberg; Jonathan Rosand; Joshua N Goldstein; David F M Brown
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-03-29
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  30     ISSN:  1532-8171     ISO Abbreviation:  Am J Emerg Med     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-11     Completed Date:  2012-08-20     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  545-52     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
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MeSH Terms
Aged, 80 and over
Cerebral Hemorrhage / complications,  physiopathology*
Enzyme-Linked Immunosorbent Assay
Middle Aged
Myocardial Ischemia / etiology,  physiopathology*
Prospective Studies
Risk Factors
Troponin I / blood
Troponin T / blood
Grant Support
Reg. No./Substance:
0/Troponin I; 0/Troponin T

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