| Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective. | |
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MedLine Citation:
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PMID: 18701939 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Myocardial infarction is the leading cause of mortality in Western societies with annual expenditures of $431.8 billion spent on coronary artery disease in man. Therapeutics to combat infarction from myocardial injury, based on studies of ischemic preconditioning (IPC), are currently in progress. Hence, this review provides an update on IPC, including general and molecular mechanisms responsible for IPC and the effects of IPC in models of aging or disease. A summary of therapeutics shown to possess efficacy in preclinical and clinical trials and future directions of studies regarding cardiac IPC are also discussed. |
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Authors:
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Eric R Gross; Garrett J Gross |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Drug discovery today. Disease mechanisms Volume: 4 ISSN: 1740-6765 ISO Abbreviation: - Publication Date: 2007 |
Date Detail:
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Created Date: 2009-3-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235075 Medline TA: Drug Discov Today Dis Mech Country: - |
Other Details:
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Languages: ENG Pagination: 165-174 Citation Subset: - |
Affiliation:
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Medical College of Wisconsin, Department of Pharmacology and Toxicology, Milwaukee, WI 53226. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HL008311-42//NHLBI NIH HHS; R37 HL074314-05//NHLBI NIH HHS |
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