Document Detail


Ischemic Preconditioning And Myocardial Infarction: An Update and Perspective.
MedLine Citation:
PMID:  18701939     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Myocardial infarction is the leading cause of mortality in Western societies with annual expenditures of $431.8 billion spent on coronary artery disease in man. Therapeutics to combat infarction from myocardial injury, based on studies of ischemic preconditioning (IPC), are currently in progress. Hence, this review provides an update on IPC, including general and molecular mechanisms responsible for IPC and the effects of IPC in models of aging or disease. A summary of therapeutics shown to possess efficacy in preclinical and clinical trials and future directions of studies regarding cardiac IPC are also discussed.
Authors:
Eric R Gross; Garrett J Gross
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Drug discovery today. Disease mechanisms     Volume:  4     ISSN:  1740-6765     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2009-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235075     Medline TA:  Drug Discov Today Dis Mech     Country:  -    
Other Details:
Languages:  ENG     Pagination:  165-174     Citation Subset:  -    
Affiliation:
Medical College of Wisconsin, Department of Pharmacology and Toxicology, Milwaukee, WI 53226.
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Grant Support
ID/Acronym/Agency:
R01 HL008311-42//NHLBI NIH HHS; R37 HL074314-05//NHLBI NIH HHS

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