| Ischemic effects of transcatheter arterial embolization with N-butyl cyanoacrylate-lipiodol on the colon in a Swine model. | |
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MedLine Citation:
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PMID: 20429002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to assess the safety of transcatheter arterial embolization (TAE) with n-butyl cyanoacrylate-lipiodol (NBCA-Lp) for the large bowel and to investigate the vital response to NBCA-Lp in a swine model. In nine swine, nine arteries nourishing the colon were embolized with NBCA-Lp (1 ml of NBCA mixed with 4 ml of lipiodol): sigmoid-rectal branch artery in six swine, right colic branch artery in two, and middle colic branch artery in one. The amount of NBCA-Lp was 0.1-0.4 ml. Sacrifice was conducted 3 days after TAE to identify histological infarction. Classification was conducted retrospectively: group A, vasa recta without NBCA-Lp embolization despite TAE; group B, three or fewer vasa recta with NBCA-Lp embolization; and group C, five or more vasa recta with NBCA-Lp embolization. In one swine in group A, no necrotic focus was observed. In group B, three of four swine experienced no ischemic damage. The remaining one swine experienced necrosis of mucosal and submucosal layers in one-fourth of the circumference. In group C, all four swine with marginal artery and five vasa recta or more embolized experienced total necrosis of mucosa, submucosa, and smooth muscle layers of the whole colonic circumference. Significant difference on the extent of ischemic damage was observed between groups B and C (P < 0.05). Microscopically, NBCA-Lp induced acute vasculitis. Embolization of three or fewer vasa recta with NBCA-Lp induced no ischemic damage or limited necrosis, whereas embolization of five or more vasa recta with NBCA-Lp induced extensive necrosis. |
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Authors:
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Akira Ikoma; Nobuyuki Kawai; Morio Sato; Tetsuo Sonomura; Hiroki Minamiguchi; Motoki Nakai; Isao Takasaka; Kouhei Nakata; Shinya Sahara; Naohisa Sawa; Shintaro Shirai; Ichiro Mori |
Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-04-30 |
Journal Detail:
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Title: Cardiovascular and interventional radiology Volume: 33 ISSN: 1432-086X ISO Abbreviation: Cardiovasc Intervent Radiol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-07 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003538 Medline TA: Cardiovasc Intervent Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 1009-15 Citation Subset: IM |
Affiliation:
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Department of Radiology, Wakayama Medical University, Wakayama-shi, Wakayama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biopsy, Needle Catheterization / methods Colon / blood supply*, pathology Colon, Sigmoid / blood supply, pathology Disease Models, Animal Embolization, Therapeutic / adverse effects*, methods Enbucrilate / adverse effects, pharmacology* Female Immunohistochemistry Ischemia / etiology, pathology Mesenteric Artery, Superior / drug effects, pathology* Probability Random Allocation Rectum / blood supply, pathology Risk Assessment Statistics, Nonparametric Swine |
| Chemical | |
Reg. No./Substance:
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6606-65-1/Enbucrilate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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