Document Detail


Ischemic conditioning protects the uremic heart in a rodent model of myocardial infarction.
MedLine Citation:
PMID:  22319109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Outcomes after acute myocardial infarction in patients with chronic kidney disease are extremely poor. Ischemic conditioning techniques are among the most powerful cytoprotective strategies discovered to date. However, experimental data suggest that comorbidity may attenuate the protective effects of ischemic conditioning.
METHODS AND RESULTS: We conducted investigations into the effects of chronic uremia on myocardial infarct size and the protective effects of ischemic preconditioning (IPC), remote ischemic preconditioning, and ischemic postconditioning in 2 rodent models of chronic uremia. In addition, a limited investigation into the signaling mechanisms involved in cardioprotection after IPC was performed in both uremic and nonuremic animals. Myocardial infarct size was increased in uremic animals, but all 3 conditioning strategies (IPC, remote IPC, ischemic postconditioning) proved highly efficacious in reducing myocardial infarct size (relative reduction, 86%, 39%, and 65% [P<0.005, P<0.05, and P<0.05], respectively). Moreover, some protocols (IPC and ischemic postconditioning) appeared to be more effective in uremic than in sham (nonuremic) animals. Analysis of the signaling mechanisms revealed that components of both the reperfusion injury salvage kinase and survivor activating factor enhancement pathways were similarly upregulated in both uremic and nonuremic animals after an IPC stimulus.
CONCLUSION: Conditioning strategies may present the best opportunity to improve outcomes for patients with chronic kidney disease after an acute coronary syndrome.
Authors:
Conor J Byrne; Kieran McCafferty; Julius Kieswich; Steven Harwood; Petros Andrikopoulos; Martin Raftery; Christoph Thiemermann; Muhammad M Yaqoob
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Publication Detail:
Type:  Journal Article     Date:  2012-02-08
Journal Detail:
Title:  Circulation     Volume:  125     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-05-01     Revised Date:  2012-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1256-65     Citation Subset:  AIM; IM    
Affiliation:
Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, UK. c.byrne@qmul.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Acute Coronary Syndrome / pathology,  therapy
Animals
Chronic Disease
Disease Models, Animal
Ischemic Preconditioning, Myocardial / methods*
Male
Myocardial Infarction / pathology,  therapy*
Myocardial Ischemia / etiology,  pathology,  therapy*
Myocardium / pathology
Rats
Rats, Wistar
Renal Insufficiency, Chronic / complications
Reperfusion Injury / pathology,  prevention & control*
Uremia / complications*
Comments/Corrections
Comment In:
Circulation. 2012 Mar 13;125(10):1215-6   [PMID:  22319108 ]
Circulation. 2012 Sep 25;126(13):e212; author reply e213   [PMID:  23008475 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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