Document Detail

Ischemic colitis: clinical presentation, localization in relation to risk factors, and long-term results.
MedLine Citation:
PMID:  21882031     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ischemic colitis is commonly thought to occur most often in the left hemicolon close to the splenic flexure owing to insufficient blood supply near Griffith's point. This study investigates the colorectal localization pattern, the risk factors, and the long-term outcome of histologically proven ischemic colitis.
METHODS: Between 1996 and 2004, a total of 49 patients with a median age of 69 years (range 26-94 years) with colonoscopically assessed and histologically proven ischemic colitis were identified on behalf of the pathology database. Long-term results of 43 patients were evaluated retrospectively after a median interval of 79 months (range 6-163 months).
RESULTS: In 27 patients (55%) more than one location was affected. We found 98 affected locations in 49 patients. The distribution of ischemic colitis in our group shows no significantly preferred location. In an exploratory analysis, the cecum, ascending colon, and right flexure were affected significantly more often if intake of a nonsteroidal antiinflammatory drug (NSAID) is documented. There was no association between the location of ischemic colitis and a history of smoking, peripheral artery occlusive disease, coronary heart disease, diabetes, or malignant tumor.
CONCLUSIONS: Ischemic colitis seems not to have a predisposing site of occurrence in the colorectum, especially Griffith's point which was not afflicted significantly more often than other sites. Frequently, ischemic colitis afflicts more than one colonic location. In patients being treated with NSAIDs, ischemic colitis was observed significantly more often in the right hemicolon. Recurrence of ischemic colitis seems to be rare.
Philippe M Glauser; Petra Wermuth; Gieri Cathomas; Evelyn Kuhnt; Samuel A Käser; Christoph A Maurer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  35     ISSN:  1432-2323     ISO Abbreviation:  World J Surg     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-12     Completed Date:  2012-05-29     Revised Date:  2013-01-08    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2549-54     Citation Subset:  IM    
Department of Surgery, Hospital of Liestal (affiliated with the University of Basel), 4410, Liestal, Switzerland.
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MeSH Terms
Aged, 80 and over
Colitis, Ischemic / diagnosis*,  etiology,  pathology,  therapy
Follow-Up Studies
Middle Aged
Retrospective Studies
Risk Factors
Treatment Outcome
Comment In:
World J Surg. 2012 Dec;36(12):2949-50; author reply 2951   [PMID:  22864568 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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