Document Detail

Ischemia-modified albumin in patients with hyperthyroidism and hypothyroidism.
MedLine Citation:
PMID:  22863438     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The relationship between ischemia-modified albumin (IMA) and thyroid dysfunction remains uncertain. This study aimed to investigate the influence of overt hypothyroidism (Oho), overt hyperthyroidism (Ohe), and their treatments on serum IMA levels.
METHODS: A total of 35 untreated patients with Ohe, 35 untreated patients with Oho, and 35 control subjects were enrolled in the study. C-reactive protein (CRP), homocysteine (Hcy), IMA, and lipid profiles were measured and evaluated before and after treatment.
RESULTS: CRP, Hcy, and IMA levels and lipid profiles were higher in patients with Oho than in euthyroid or Ohe subjects (p<0.05). Basal IMA levels were reduced after treatments in all patients (p<0.05). In Ohe patients, serum IMA levels were positively correlated with free triiodothyronine (r=0.424, p=0.011) and free thyroxine (r=0.567, p<0.001) levels. In Oho patients, serum IMA levels were inversely correlated with free triiodothyronine (r=-0.555, p=0.001) and free thyroxine (r=-0.457, p=0.006) but positively correlated with anti-thyroid peroxidase antibody, C-reactive protein, and homocysteine levels (p<0.05). Linear regression analyses showed that free triiodothyronine was the most important factor affecting serum IMA levels in Ohe (β=0.694, p=0.019) and in Oho (β=-0.512, p=0.025).
CONCLUSIONS: IMA levels are increased in patients with thyroid dysfunction, particularly in overt hypothyroidism. Thyroid dysfunction has a significant impact on the oxidative stress status.
Shao-gang Ma; Liu-xue Yang; Feng Bai; Wei Xu; Bing Hong
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Publication Detail:
Type:  Journal Article     Date:  2012-05-15
Journal Detail:
Title:  European journal of internal medicine     Volume:  23     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-06     Completed Date:  2013-01-04     Revised Date:  2014-04-24    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e136-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
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MeSH Terms
Antithyroid Agents / therapeutic use
Autoantibodies / blood
Biological Markers / blood
C-Reactive Protein / analysis
Case-Control Studies
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Homocysteine / blood
Hyperthyroidism / blood*,  therapy
Hypothyroidism / blood*,  therapy
Iodide Peroxidase / immunology
Methimazole / therapeutic use
Middle Aged
Oxidative Stress
Serum Albumin
Thyroxine / blood,  therapeutic use
Triglycerides / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Antithyroid Agents; 0/Autoantibodies; 0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Serum Albumin; 0/Triglycerides; 0/anti-thyroglobulin; 0/ischemia-modified albumin; 06LU7C9H1V/Triiodothyronine; 0LVT1QZ0BA/Homocysteine; 554Z48XN5E/Methimazole; 9007-41-4/C-Reactive Protein; EC Peroxidase; Q51BO43MG4/Thyroxine
Comment In:
Eur J Intern Med. 2014 Mar;25(3):e42-3   [PMID:  24209689 ]

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