Document Detail

Ischemia modified albumin in normal pregnancy and preeclampsia.
MedLine Citation:
PMID:  18484421     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Ischemia-modified albumin (IMA) has emerged as a new biomarker of myocardial ischemia. Currently, no information is available on maternal IMA levels during normal and complicated pregnancy. Preeclampsia is associated with ischemia and increased formation of free radicals in the placenta. We therefore hypothesized that production of IMA may occur in women with preeclampsia.
METHODS: Serum IMA and albumin concentrations were assessed in 12 patients with preeclampsia, 12 normal pregnant controls, and 12 nonpregnant controls. IMA levels were compared between groups and corrected for albumin by multivariate regression analysis.
RESULTS: Mean IMA levels were elevated in normal pregnant controls (107.3 U/mL; 95% CI, 102.5 to 112.01), compared with nonpregnant controls (94.5 U/mL; CI, 89.4 to 99.6; p = 0.015). In patients with preeclampsia, IMA levels were similar to those in normal pregnant controls (109.7 U/mL; CI, 102.2 to 117.2; p = 0.65). Also, no difference in IMA levels was observed between women with preeclampsia who delivered small-for-gestational-age (SGA) infants (99.0 U/mL; CI, 87.9 to 110.1; p = 0.13) and women with preeclampsia but without SGA.
CONCLUSION: Serum IMA, which has been advocated as a clinical marker of cardiac ischemia, appears to be elevated during normal pregnancy. We found no significant relationship between IMA levels and preeclampsia, in women with or without SGA infants.
Bas B van Rijn; Arie Franx; J Marko Sikkema; Herman J M van Rijn; Hein W Bruinse; Hieronymus A M Voorbij
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  27     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-07-01     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  159-67     Citation Subset:  IM    
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MeSH Terms
Albumins / analysis*
Biological Markers / blood
Case-Control Studies
Ischemia / blood*
Placenta / blood supply*
Pre-Eclampsia / blood*,  physiopathology
Pregnancy / blood*,  physiology
Reg. No./Substance:
0/Albumins; 0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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