Document Detail

Ischemia imaging and plaque imaging in diabetes: complementary tools to improve cardiovascular risk management.
MedLine Citation:
PMID:  16249559     Owner:  NLM     Status:  MEDLINE    
Cardiovascular disease is the most frequent cause of death and disability in diabetes, and the morbidity and mortality for coronary artery disease (CAD) in this population is two to four times higher than in nondiabetic subjects. Traditional risk factors do not fully explain the level of cardiovascular risk, and coronary disease events are often silent in diabetic patients. Thus, research has recently focused on improving the risk assessment of an individual patient with new tools in an effort to better identify subjects at highest risk and in need of aggressive management. Cardiovascular imaging has proven very helpful in this regard. Traditional methods to assess CAD are based on detection of obstructive luminal disease responsible for myocardial ischemia. However, acute coronary syndromes often occur in the absence of luminal stenoses. Hence, the utilization of imaging methodologies to visualize atherosclerosis in its presymptomatic stages has received mounting attention in recent years. In this article, we review the current literature on the utility of traditional imaging modalities for obstructive CAD (nuclear and echocardiographic stress testing) as well as atherosclerosis plaque imaging with carotid intima-media thickness and coronary artery calcium for risk stratification of diabetic patients.
Paolo Raggi; Antonio Bellasi; Carlo Ratti
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Diabetes care     Volume:  28     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-26     Completed Date:  2006-01-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2787-94     Citation Subset:  IM    
Section of Cardiology, Tulane University School of Medicine, Tulane University, New Orleans, LA 70112, USA.
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MeSH Terms
Cardiovascular Diseases / epidemiology,  etiology*
Coronary Artery Disease / complications,  diagnosis*,  pathology,  ultrasonography
Diabetes Complications*
Diabetes Mellitus
Diabetes Mellitus, Type 1 / complications
Diabetes Mellitus, Type 2 / complications
Echocardiography, Stress
Magnetic Resonance Angiography
Myocardial Ischemia / radiography*
Organophosphorus Compounds / diagnostic use
Organotechnetium Compounds / diagnostic use
Risk Management*
Technetium Tc 99m Sestamibi / diagnostic use
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon
Tunica Intima / pathology
Tunica Media / pathology
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/Thallium Radioisotopes; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane; 109581-73-9/Technetium Tc 99m Sestamibi
Comment In:
Diabetes Care. 2006 May;29(5):1187; author reply 1188   [PMID:  16685801 ]

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