Document Detail

Ischemia and reperfusion of the lung tissues induced increase of lung permeability and lung edema is attenuated by dimethylthiourea (PP69).
MedLine Citation:
PMID:  20430163     Owner:  NLM     Status:  MEDLINE    
This study sought to determine whether oxygen radical scavengers of dimethylthiourea (DMTU), superoxide dismutase (SOD), or catalase (CAT) pretreatment attenuated ischemia-reperfusion (I/R)-induced lung injury. After isolation from a Sprague-Dawley rat, the lungs were perfused through the pulmonary artery cannula with rat whole blood diluted 1:1 with a physiological salt solution. An acute lung injury was induced by 10 minutes of hypoxia with 5% CO2-95% N2 followed by 65 minutes of ischemia and then 65 minutes of reperfusion. I/R significantly increased microvascular permeability as measured by the capillary filtration coefficient (Kfc), lung weight-to-body weight ratio (LW/BW), and protein concentration in bronchoalveolar lavage fluid (PCBAL). DMTU pretreatment significantly attenuated the acute lung injury. The capillary filtration coefficient (P<.01), LW/BW (P<.01) and PCBAL (P<.05) were significantly lower among the DMTU-treated rats than hosts pretreated with SOD or CAT. The possible mechanisms of the protective effect of DMTU in I/R-induced lung injury may relate to the permeability of the agent allowing it to scavenge intracellular hydroxyl radicals. However, whether superoxide dismutase or catalase antioxidants showed protective effects possibly due to their impermeability of the cell membrane not allowing scavenging of intracellular oxygen radicals.
K H Chen; D Chao; C F Liu; C F Chen; D Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  42     ISSN:  1873-2623     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  748-50     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
Department of Nursing and Management, Jen-Teh Junior College of Medicine, Miouli County, Taiwan.
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MeSH Terms
Body Weight
Edema / drug therapy,  etiology*
Free Radical Scavengers / therapeutic use*
Lung / anatomy & histology
Lung Injury / drug therapy,  etiology*
Microcirculation / drug effects,  physiology
Organ Size
Rats, Sprague-Dawley
Reperfusion Injury / complications,  physiopathology*
Thiourea / analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Free Radical Scavengers; 61805-96-7/1,3-dimethylthiourea; 62-56-6/Thiourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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